Liver Unit, Cathay General Hospital Medical Center, Taipei, Taiwan.
Genes Immun. 2010 Jan;11(1):87-93. doi: 10.1038/gene.2009.65. Epub 2009 Aug 20.
Vitamin D exhibits immunomodulatory and antiproliferative effects through vitamin D receptor (VDR) in chronic infections and cancers. We genotyped the BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236) polymorphisms of VDR gene in 250 Taiwanese chronic hepatitis B virus (HBV) carriers who were categorized into six phenotypes. After adjustment for age and sex, the frequencies of the VDR B/b, B/a, B/T, B/a/T in patients with hepatitis flare(s) were lower than those without (7 vs 20%, P=0.009; 1 vs 9%, P=0.004; 3 vs 10%, P=0.007; 1 vs 9%, P=0.005, respectively); in contrast, T/t, A/T, A/t, b/A/t were higher in flare(s) (8 vs 3%, P=0.003; 49 vs 34%, P=0.027; 2 vs 1%, P=0.004; 0.5 vs 0%, P=0.001, respectively). In addition, B/b, B/B, T/t, b/A, B/a, B/A, B/T, B/t, A/t, b/A/T, B/a/T, B/A/T, B/A/t, b/A/t were higher in patients positive for HBeAg. The distribution of VDR genotypes was comparable between patients with and without hepatocellular carcinoma (HCC). VDR gene polymorphisms are associated with distinct clinical phenotypes in Taiwanese HBV carriers but not with HCC development.
维生素 D 通过维生素 D 受体 (VDR) 在慢性感染和癌症中表现出免疫调节和抗增殖作用。我们对 250 名台湾慢性乙型肝炎病毒 (HBV) 携带者的 VDR 基因 BsmI (rs1544410)、ApaI (rs7975232) 和 TaqI (rs731236) 多态性进行了基因分型，并将这些携带者分为六个体型。在调整年龄和性别后，有肝炎发作的患者中 VDR B/b、B/a、B/T、B/a/T 的频率低于无肝炎发作的患者（7%比 20%，P=0.009；1%比 9%，P=0.004；3%比 10%，P=0.007；1%比 9%，P=0.005）；相反，T/t、A/T、A/t、b/A/t 在肝炎发作中更高（8%比 3%，P=0.003；49%比 34%，P=0.027；2%比 1%，P=0.004；0.5%比 0%，P=0.001）。此外，B/b、B/B、T/t、b/A、B/a、B/A、B/T、B/t、A/t、b/A/T、B/a/T、B/A/T、B/A/t、b/A/t 在 HBeAg 阳性患者中更高。VDR 基因型的分布在 HBV 携带者中与 HCC 患者无差异。VDR 基因多态性与台湾 HBV 携带者的不同临床表型相关，但与 HCC 发生无关。
