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维生素 D 受体基因多态性与儿童龋齿风险的关联：系统评价和荟萃分析。

Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and meta-analysis.

机构信息

Department of Preventive Dentistry, Shanghai Stomatological Hospital Fudan University, Shanghai, China.

Department of Stomatology, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, China.

出版信息

BMC Pediatr. 2024 Oct 11;24(1):650. doi: 10.1186/s12887-024-05127-w.

DOI:10.1186/s12887-024-05127-w

PMID:39394075

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11468088/

Abstract

BACKGROUND

To investigate the association of vitamin D receptor (VDR) gene polymorphism with caries risk in children(< 18 years).

METHODS

The electronic databases PubMed, Cochrane, EMBASE, Web of Science, CNKI, Cqvip, and Wanfang were searched for observational studies on the relationship between VDR single nucleotide polymorphism(SNP) and caries, including cohort, case-control, and cross-sectional studies. Quality assessment of selected studies was conducted using the Newcastle Ottawa scale. Odds ratios (OR) with 95% confidence intervals (CI) values for associations of individual VDR SNP with dental caries were calculated based on four genetic models: allelic, recessive, dominant, and over-dominant.

RESULTS

Of 79 studies considered, 10 (nine case-control and one cross-sectional) were selected for analysis; the studies involved seven VDR SNPs: ApaI(rs7975232),BsmI(rs1544410),FokI(rs2228570),TaqI(rs731236), TaqI/BglI(rs739837), FokI(rs10735810) and Cdx-2(rs11568820). Alleles C and T of FokI(rs10735810) were significantly differently distributed in the caries and caries-free groups (OR = 1.33, 95% CI: 1.30-2.30, P = 0.03), with CC + CT genotypes at this locus associated with greater risk of developing caries than the TT genotype (OR = 1.87, 95%CI: 1.15-3.04, P = 0.01). Further, TT + CC genotype at TaqI(rs731236) was associated with a 1.33-fold higher risk of caries development than the TC genotype (OR = 1.33, 95%CI: 1.06-1.67, P = 0.02). On subgroup analysis, the association between TaqI(rs731236) and caries risk was affected by dentition type, and ethnicity (permanent dentition: OR = 1.48, 95%CI: 1.07-2.03, P = 0.02; Asian: OR = 1.38, 95%CI: 1.02-1.87, P = 0.03;). Genotype distributions at BsmI(rs1544410), TaqI/BglI(rs739837), FokI(rs2228570), and ApaI(rs7975232) did not differ significantly between the caries and caries-free groups.

CONCLUSIONS

Caries risk could be associated with TaqI(rs731236) and FokI(rs10735810) genotypes, and TaqI(rs731236) may be a risk factor for permanent teeth caries among Asian people.

摘要

背景

探讨维生素 D 受体（VDR）基因多态性与儿童（<18 岁）龋齿风险的关系。

方法

检索电子数据库 PubMed、Cochrane、EMBASE、Web of Science、CNKI、Cqvip 和 Wanfang，以寻找 VDR 单核苷酸多态性（SNP）与龋齿关系的观察性研究，包括队列、病例对照和横断面研究。使用纽卡斯尔-渥太华量表对选定研究进行质量评估。基于等位基因、隐性、显性和过显性四种遗传模型，计算个体 VDR SNP 与龋齿相关性的优势比（OR）及其 95%置信区间（CI）值。

结果

共考虑了 79 项研究，其中 10 项（9 项病例对照和 1 项横断面）被选入分析；这些研究涉及 7 个 VDR SNP：ApaI(rs7975232)、BsmI(rs1544410)、FokI(rs2228570)、TaqI(rs731236)、TaqI/BglI(rs739837)、FokI(rs10735810)和 Cdx-2(rs11568820)。FokI(rs10735810)的等位基因 C 和 T 在龋齿组和无龋齿组中的分布存在显著差异（OR=1.33，95%CI：1.30-2.30，P=0.03），与该位点的 CC+CT 基因型相比，TT 基因型患龋齿的风险更高（OR=1.87，95%CI：1.15-3.04，P=0.01）。此外，TaqI(rs731236)的 TT+CC 基因型与龋齿发生风险增加 1.33 倍相关（OR=1.33，95%CI：1.06-1.67，P=0.02）。进一步的亚组分析显示，TaqI(rs731236)与龋齿风险的关联受牙列类型和种族的影响（恒牙列：OR=1.48，95%CI：1.07-2.03，P=0.02；亚洲人：OR=1.38，95%CI：1.02-1.87，P=0.03）。BsmI(rs1544410)、TaqI/BglI(rs739837)、FokI(rs2228570)和 ApaI(rs7975232)的基因型在龋齿组和无龋齿组之间的分布无显著差异。