Iannitti T, Palmieri B
Department of General Surgery and Surgical Specialties, Medical School and Surgical Clinic, University of Modena and Reggio Emilia, Modena, Italy.
Eur Rev Med Pharmacol Sci. 2009 Jul-Aug;13(4):245-78.
Antioxidants are chemical compounds that giving an electron to free radical molecules convert them to an harmless configuration, avoiding damaging chain reaction, which can involve lipids, proteins enzymes carbohydrates, DNA, cell and nuclear membranes up to the cell death. Being either exogenous or endogenous they are addressed to prevent the oxidation induced damage, a process that causes damage in all tissues through free radicals chemical reactivity. A lot of natural, nutraceutical or chemical compounds are being actually marketed with a lot of different claims and are prescribed by doctors or sold over the counter. Unfortunately, in the medical literature many heterogeneous published articles support the use of this class of drugs, but most of them cannot be compared or pooled to achieve statistical significance of effectiveness. Our review aims at defining the state of the art of antioxidant therapy, with specific reference on the evidence based clinical use.
抗氧化剂是一类化合物，它们通过向自由基分子提供一个电子，将其转化为无害的构型，从而避免可能涉及脂质、蛋白质、酶、碳水化合物、DNA、细胞膜和核膜直至细胞死亡的破坏性连锁反应。无论是外源性还是内源性的抗氧化剂，其作用都是防止氧化诱导的损伤，这一过程通过自由基的化学反应对所有组织造成损害。目前，许多天然、营养保健品或化学合成的抗氧化剂正在市场上销售，它们有着各种各样的宣传声称，并且由医生开处方或在柜台销售。不幸的是，医学文献中有许多不同的已发表文章支持使用这类药物，但其中大多数无法进行比较或汇总以达到有效性的统计学显著性。我们的综述旨在界定抗氧化剂治疗的现状，特别关注基于证据的临床应用。
