[Role of ACTH and glucocorticoids in providing for non-enzymatic fibrinolysis in animals under immobilization stress].

The 30-min immobilization stress was shown to raise significantly the non-enzymatic fibrinolytic activity of blood in rats. Combined with ACTH the effect is still greater. I. v. administration of 0.2 ml 0.01% solution of protaiminsulphate prevented the non-enzymatic fibrinolysis induced by the stress. Administration of ACTH after proteminsulphate again raised the fibrinolysis. This suggests that ACTH stimulates release of heparin. As the hydrocortisone administration proved ineffective, the stimulating effect of ACTH seems to have no relation to activation of glycocorticoids secretion. Glycocorticoids in this case appear to have a permissive role. This is corroborated by the data obtained with administration of protaminsulphate in 48 hrs after adrenalectomy. Neither ACTH nor hydrocortisone separately stimulated the non-enzymatic fibrinolysis in these animals. This process can be normalized in adrenalectomized animals with combined ACTH and hydrocortisone.