Kudriashov B A, Shapiro F B, Lomovskaia E G, Liapina L A
Fiziol Zh SSSR Im I M Sechenova. 1977 May;63(5):735-41.
The 30-min immobilization stress was shown to raise significantly the non-enzymatic fibrinolytic activity of blood in rats. Combined with ACTH the effect is still greater. I. v. administration of 0.2 ml 0.01% solution of protaiminsulphate prevented the non-enzymatic fibrinolysis induced by the stress. Administration of ACTH after proteminsulphate again raised the fibrinolysis. This suggests that ACTH stimulates release of heparin. As the hydrocortisone administration proved ineffective, the stimulating effect of ACTH seems to have no relation to activation of glycocorticoids secretion. Glycocorticoids in this case appear to have a permissive role. This is corroborated by the data obtained with administration of protaminsulphate in 48 hrs after adrenalectomy. Neither ACTH nor hydrocortisone separately stimulated the non-enzymatic fibrinolysis in these animals. This process can be normalized in adrenalectomized animals with combined ACTH and hydrocortisone.
30分钟的固定应激被证明能显著提高大鼠血液中的非酶促纤维蛋白溶解活性。与促肾上腺皮质激素（ACTH）联合使用时，效果更明显。静脉注射0.2毫升0.01%的硫酸鱼精蛋白溶液可防止应激诱导的非酶促纤维蛋白溶解。在注射硫酸鱼精蛋白后再给予ACTH，纤维蛋白溶解又会升高。这表明ACTH刺激肝素的释放。由于给予氢化可的松被证明无效，ACTH的刺激作用似乎与糖皮质激素分泌的激活无关。在这种情况下，糖皮质激素似乎起到允许作用。肾上腺切除术后48小时给予硫酸鱼精蛋白所获得的数据证实了这一点。单独给予ACTH或氢化可的松均未刺激这些动物的非酶促纤维蛋白溶解。联合使用ACTH和氢化可的松可使肾上腺切除动物的这一过程恢复正常。
