Cheplick Susan, Kwon Young-In, Bhowmik Prasanta, Shetty Kalidas
Department of Plant, Soil, and Insect Sciences, University of Massachusetts, Amherst, MA 01003, USA.
Bioresour Technol. 2010 Jan;101(1):404-13. doi: 10.1016/j.biortech.2009.07.068. Epub 2009 Aug 19.
Fruit extracts of different strawberry cultivars were evaluated for their potential to contribute to the dietary management of hyperglycemia-linked to type 2 diabetes and related hypertension. In vitro inhibition of alpha-amylase, alpha-glucosidase, and angiotensin-1-converting enzyme (ACE) activity was evaluated using fruit extracts and correlated to phenolic content and antioxidant activity. There were significant differences between cultivars in both phenolic-linked antioxidant activity and inhibitory activity for the targeted disease relevant enzymes. Honeoye, Idea, and Jewel cultivars exhibited moderate alpha-amylase inhibition. Strawberry cultivars, in general, exhibited uniform alpha-glucosidase inhibition with Ovation having the highest inhibitory activity. Water extracts of Jewel and Ovation cultivars had moderate ACE inhibition compared to low inhibition observed in other cultivars. Strawberry cultivars with combined inhibitory potential against alpha-glucosidase and ACE and with moderate or low alpha-amylase inhibitory potential could be targeted for potential management of hyperglycemia-linked type 2 diabetes and related complication of hypertension.
对不同草莓品种的果实提取物进行了评估，以确定其对与2型糖尿病相关的高血糖症及相关高血压进行饮食管理的潜在作用。使用果实提取物评估了其对α-淀粉酶、α-葡萄糖苷酶和血管紧张素转换酶（ACE）活性的体外抑制作用，并将其与酚类含量和抗氧化活性相关联。在酚类相关抗氧化活性和对目标疾病相关酶的抑制活性方面，不同品种之间存在显著差异。哈尼伊、爱达和宝石品种表现出适度的α-淀粉酶抑制作用。总体而言，草莓品种对α-葡萄糖苷酶的抑制作用较为一致，其中奥vation的抑制活性最高。与其他品种中观察到的低抑制作用相比，宝石和奥vation品种的水提取物具有适度的ACE抑制作用。对α-葡萄糖苷酶和ACE具有联合抑制潜力且对α-淀粉酶具有中度或低度抑制潜力的草莓品种，可作为潜在管理与2型糖尿病相关的高血糖症及高血压相关并发症的目标。
