Dong Jin-Yan, Wang Li-Mei, Song Hong-Chuang, Shen Kai-Ze, Zhou Yong-Ping, Wang Le, Zhang Ke-Qin
Laboratory for Conservation and Utilization of Bio-Resources, Yunnan University, Kunming, PR China.
Chem Biodivers. 2009 Aug;6(8):1216-23. doi: 10.1002/cbdv.200800184.
Two novel diastereoisomeric bicyclic ketals, colomitides A and B (1 and 2, resp.), together with the known (4RS)-3,4-dihydro-4,8-dihydroxynaphthalen-1(2H)-one (3) and preussomerin E (4), were isolated from liquid cultures of an unidentified freshwater fungus YMF 1.01029. Colomitides possess an unusual 2,7-dioxabicyclo[3.2.1]octane skeleton. The chemical structures and relative configurations of compounds 1 and 2 were elucidated by spectroscopic means, including 2D-NMR (HMBC, HMQC, TOCSY, ROESY, and (1)H,(1)H-COSY). Compounds 1, 2, and 4 showed noticeable antifungal and antibacterial activities.
从一株未鉴定的淡水真菌YMF 1.01029的液体培养物中分离得到了两种新型非对映异构双环缩酮，即可乐米肽A和B（分别为1和2），以及已知的(4RS)-3,4-二氢-4,8-二羟基萘-1(2H)-酮（3）和普氏菌素E（4）。可乐米肽具有不寻常的2,7-二氧杂双环[3.2.1]辛烷骨架。通过光谱手段，包括二维核磁共振（HMBC、HMQC、TOCSY、ROESY和(1)H,(1)H-COSY）阐明了化合物1和2的化学结构及相对构型。化合物1、2和4表现出显著的抗真菌和抗菌活性。
