Dong Jin-Yan, Song Hong-Chuan, Li Jian-Hua, Wang Chun-Ren, Sun Rong, Tang Yu-Shu, Shen Kai-Ze, Wang Le, Wang Li-Mei, Zhou Yong-Ping, Li Lei, Zhang Ke-Qin
Laboratory for Conservation and Utilization of Bio-Resources, and Key Laboratory for Microbial Resources of the Chinese Ministry of Education, Yunnan University, Kunming 650091, P. R. China.
Chem Biodivers. 2009 Apr;6(4):569-77. doi: 10.1002/cbdv.200800028.
Two novel naphthalene-containing compounds, colelomycerones A and B (1 and 2, resp.), and three known metabolites, including preussomerin D (3), (2RS,2'SR,3'E,3SR,4E,8E)-1-O-(beta-D-glucopyranosyl)-3-hydroxy-2-[(2-hydroxyoctadec-3-enoyl)amino]-9-methyloctadeca-4,8-diene (4), and 3beta-hydroxy-5alpha,8alpha-epidioxyergosta-6,22-diene (5), were isolated from the culture broth of an unidentified freshwater water fungus YMF 1.01029. This fungus was collected from a decaying branch of an unidentified tree near Lake Fuxian in Yunnan Province, China. The structures of these five compounds were determined on the basis of their spectroscopic and mass-spectrometric data. Colelomycerones A and B (1 and 2, resp.) represent unprecendented examples of naphthalene-1,2-diones with novel cyclic acetals. Compounds 1-3 showed noticeable antifungal and antibacterial activities.
从一株未鉴定的淡水真菌YMF 1.01029的培养液中分离出两种新型含萘化合物，即colelomycerones A和B（分别为1和2），以及三种已知代谢产物，包括preussomerin D（3）、(2RS,2'SR,3'E,3SR,4E,8E)-1-O-(β-D-吡喃葡萄糖基)-3-羟基-2-[(2-羟基十八碳-3-烯酰基)氨基]-9-甲基十八碳-4,8-二烯（4）和3β-羟基-5α,8α-环氧麦角甾-6,22-二烯（5）。该真菌采自中国云南省抚仙湖附近一棵未鉴定树木的腐烂树枝。根据这些化合物的光谱和质谱数据确定了它们的结构。Colelomycerones A和B（分别为1和2）是具有新型环状缩醛的萘-1,2-二酮的前所未有的例子。化合物1-3表现出显著的抗真菌和抗菌活性。
