Chartrel N, Clabaut M, Boismare F, Schrub J C
Laboratory of Foeto-Maternal Physiopathology, Faculty of Sciences, University of Rouen, France.
Biol Neonate. 1990;57(3-4):218-23. doi: 10.1159/000243194.
The aim of this study was to determine if placental prostanoids could mediate the vasodilating action of an alpha-1-adrenoceptor antagonist, nicergoline (400 micrograms/kg i.p.), during late pregnancy in streptozotocin-induced diabetic rats (40 mg/kg i.v.). Placental prostanoid concentrations were evaluated by radioimmunoassay. Prostaglandin E2 levels showed a highly significant increase in diabetic and nondiabetic rats treated with nicergoline (p less than 0.001). 6-Keto-PGF1 alpha concentrations were slightly increased in diabetic rats compared to controls, and this increase was reversed by both nicergoline and insulin treatments. In all groups studied thromboxane B2 levels were comparable. It is concluded that prostaglandin E2 could mediate the vasodilating action of nicergoline on the placental irrigation and, therefore, improved the hemodynamic state of this organ in diabetic rats.
本研究的目的是确定在链脲佐菌素诱导的糖尿病大鼠（静脉注射40mg/kg）妊娠晚期，胎盘前列腺素是否能介导α-1-肾上腺素能受体拮抗剂尼麦角林（腹腔注射400μg/kg）的血管舒张作用。通过放射免疫分析法评估胎盘前列腺素浓度。在用尼麦角林治疗的糖尿病和非糖尿病大鼠中，前列腺素E2水平显著升高（p<0.001）。与对照组相比，糖尿病大鼠中6-酮-前列腺素F1α浓度略有升高，尼麦角林和胰岛素治疗均可逆转这种升高。在所有研究组中，血栓素B2水平相当。结论是，前列腺素E2可介导尼麦角林对胎盘灌注的血管舒张作用，从而改善糖尿病大鼠该器官的血液动力学状态。
