Kubota K, Sugaya K, Hotta K
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
Jpn J Pharmacol. 1988 Dec;48(4):491-3. doi: 10.1254/jjp.48.491.
In order to examine the effect of cimetidine on the production of prostanoids in the stomach mucosa, the amounts of prostaglandin (PG) E2, F1 alpha and thromboxane (TX) B2 were determined after the specimens from the rat stomach corpus were incubated in the presence of cimetidine. Cimetidine significantly stimulated the production of PGE2 in the specimens at a concentration of 10 microM, but did not significantly affect the production of PGF1 alpha and TXB2 at concentrations of 1 to 100 microM.
为了研究西咪替丁对胃黏膜中前列腺素生成的影响，在西咪替丁存在的情况下，将大鼠胃体标本孵育后，测定前列腺素（PG）E2、F1α和血栓素（TX）B2的含量。西咪替丁在浓度为10微摩尔时显著刺激标本中PGE2的生成，但在1至100微摩尔浓度时对PGF1α和TXB2的生成没有显著影响。
