Shen Yu Jia, Li Wei Guo, Zhang Hui, Li Bin, Yuan Hong Xu, Zhang Jiang Jiang
College of Life Sciences, Henan Normal University, Henan Xinxiang 453007.
Fen Zi Xi Bao Sheng Wu Xue Bao. 2009 Jun;42(3-4):179-85.
(-)-Epigallocatechin-3-gallate (EGCG), a main constituent of green tea polyphenols, plays important roles in antioxidative, anti-senescence, anti-tumor, anti-inflammation and bacterail action. In this study, effects of EGCG on the expression of IL-1beta gene and the IL-1beta level at wound sites during cutaneous wound healing were investigated with histological stain, ELISA and RT-PCR technique. The results show that EGCG (50 mg/L) inhibited the expression of IL-1beta gene and reduced the IL-beta level at wound sites at 72 h after cutaneous wound, but not change the expression of IL-1beta gene and the IL-1beta level at early stage (< or =24 h).
（-）-表没食子儿茶素-3-没食子酸酯（EGCG）是绿茶多酚的主要成分，在抗氧化、抗衰老、抗肿瘤、抗炎和抗菌作用中发挥重要作用。本研究采用组织学染色、酶联免疫吸附测定（ELISA）和逆转录-聚合酶链反应（RT-PCR）技术，研究了EGCG对皮肤伤口愈合过程中伤口部位白细胞介素-1β（IL-1β）基因表达和IL-1β水平的影响。结果表明，EGCG（50毫克/升）在皮肤伤口后72小时抑制了伤口部位IL-1β基因的表达并降低了IL-β水平，但在早期（≤24小时）并未改变IL-1β基因的表达和IL-1β水平。
