Zamfir Cristina
Institutul de Diabet Prof. Dr. N. Paulescu Bucureşti.
Oftalmologia. 2009;53(2):8-12.
Hyperglycemia becomes pathogenic for specific cells through multiple biochemical mechanisms. First, we describe the activation of polyol pathway. Then, we discuss the intracellular production of advanced glycation end product precursors and the activation of protein kinase C system. Also, we talk about the increased hexosamine pathway activity. All of these mechanisms are initiated by the same phenomena, the hyperglycemia-induced mitochondrial production of superoxid which is equal with increased intracellular oxidative stress.
高血糖通过多种生化机制对特定细胞产生致病性。首先，我们描述多元醇途径的激活。然后，我们讨论晚期糖基化终产物前体的细胞内产生以及蛋白激酶C系统的激活。此外，我们还会谈到己糖胺途径活性的增加。所有这些机制都是由相同的现象引发的，即高血糖诱导的线粒体超氧化物产生，这等同于细胞内氧化应激的增加。
