Research Center for Biochemistry and Nutrition in Metabolic Diseases, Depatrment of Biochemistry, Kashan University of Medical Sciences, Kashan, Iran.
Department of Kinesiology, University of Calgary, Calgary, AB, Canada.
J Cell Physiol. 2019 Jun;234(6):8522-8532. doi: 10.1002/jcp.27801. Epub 2018 Nov 27.
Diabetic retinopathy (DR) is a major cause of vision reduction in diabetic patients. Hyperglycemia is a known instigator for the development of DR, even though the role of oxidative stress pathways in the pathogenesis of DR is established. The studies indicate that microRNAs (miRNAs) are significant to the etiology of DR; changes in miRNAs expression levels may be associated with onset and progression of DR. In addition, miRNAs have emerged as a useful disease marker due to their availability and stability in detecting the severity of DR. The relationship between miRNAs expression levels and oxidative stress pathways has been investigated in several studies. The aim of this study is the examination of function and expression levels of target miRNAs in oxidative stress pathway and pathogenesis of diabetic retinopathy.
糖尿病性视网膜病变（DR）是糖尿病患者视力下降的主要原因。高血糖是 DR 发展的已知诱因，尽管氧化应激途径在 DR 发病机制中的作用已得到确立。研究表明，微小 RNA（miRNA）对 DR 的病因学具有重要意义；miRNA 表达水平的变化可能与 DR 的发生和进展有关。此外，由于 miRNA 在检测 DR 严重程度方面的可用性和稳定性，它们已成为一种有用的疾病标志物。miRNA 表达水平与氧化应激途径之间的关系已在几项研究中进行了探讨。本研究的目的是研究氧化应激途径和糖尿病性视网膜病变发病机制中靶 miRNA 的功能和表达水平。
