Biro Zsolt, Balla Zsolt
Department of Ophthalmology, University of Pécs, Medical School Pécs, Hungary.
Oftalmologia. 2009;53(2):54-60.
The aim of the study was to measure the change of the foveal and perifoveal thickness of the retina in diabetic patients after uneventful phacoemulsification and PC-IOL implantation.
Retinal thickness values of the foveal and perifoveal (fovea + 3.0 mm, fovea + 6.0 mm) sectors and the minimum values were measured in a prospective study using optical coherence tomography (OCT) in 18 eyes of 18 diabetic patients who underwent cataract surgery. Phacoemulsification and "in the bag" implantation of a foldable posterior chamber intraocular lens (PC-IOL) was performed under topical anaesthesia. Data were collected one day before the operation, and postoperatively at 1, 7, 30, and 60 days. Contralateral eyes of each patient served as controls. Student's t-test was used for statistical analysis, and p < 0.05 value was considered significant.
No significant change of the thickness values could be measured one day after surgery. However, a significant increase could be detected on the postoperative 7, 30, and 60 days in the perifoveal 3.0 mm and 6.0 mm sectors either calculated alone or averaged together with the foveal values. The initial (preoperative) average value of 232.7 +/- 3.5 microm (mean +/- SEM, n=144) in the 6.0 mm perifoveal region increased to 246.0 +/- 8.2 microm (mean +/- SEM, n=120, p < 0.05) one week, to 249.9 +/- 5 1 microm (n=112, p < 0.01) one month, and to 249.5_+6.2 pm (n=104, p < 0.01) 2 months after surgery, which proved to be significant.
Our results indicate that diabetes did not influence significantly the thickening of the macular regions after uncomplicated cataract surgery. However, the postoperative perifoveal macular thickness change was found to be nonsignificantly higher in the diabetic group compared to the nondiabetic group, which might be attributed to the high sensitivity of the OCT method.
本研究旨在测量糖尿病患者在顺利完成白内障超声乳化吸除术及后房型人工晶状体（PC-IOL）植入术后视网膜中央凹及中央凹周围厚度的变化。
在一项前瞻性研究中，使用光学相干断层扫描（OCT）测量了18例接受白内障手术的糖尿病患者18只眼的视网膜中央凹及中央凹周围（中央凹+3.0mm、中央凹+6.0mm）区域的厚度值及最小值。在表面麻醉下进行白内障超声乳化吸除术及可折叠后房型人工晶状体（PC-IOL）的“囊袋内”植入。在手术前一天、术后1天、7天、30天和60天收集数据。每位患者的对侧眼作为对照。采用学生t检验进行统计学分析，p<0.05被认为具有统计学意义。
术后1天未检测到厚度值的显著变化。然而，术后7天、30天和60天，无论是单独计算还是与中央凹值一起平均计算，中央凹周围3.0mm和6.0mm区域均检测到显著增加。中央凹周围6.0mm区域的初始（术前）平均值为232.7±3.5微米（平均值±标准误，n=144），术后1周增加至246.0±8.2微米（平均值±标准误，n=120，p<0.05），术后1个月增加至249.9±5.1微米（n=112，p<0.01），术后2个月增加至249.5±6.2微米（n=104，p<0.01），差异具有统计学意义。
我们的结果表明，糖尿病对白内障手术顺利完成后黄斑区增厚无显著影响。然而，与非糖尿病组相比，糖尿病组术后中央凹周围黄斑厚度变化无显著升高，这可能归因于OCT方法的高敏感性。
