Gioia Marco, De Bernardo Maddalena, La Marca Aniello, De Luca Martina, Pagliarulo Sergio, Avella Mariagrazia, Mignone Alfredo, Rosa Nicola
Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy.
Front Med (Lausanne). 2025 Jul 21;12:1537402. doi: 10.3389/fmed.2025.1537402. eCollection 2025.
To detect the short-term impact of cataract surgery on retinal layers thickness, as the exact mechanism of fundus changes after phacoemulsification has not yet been fully clarified.
A retrospective observational study.
SUBJECTS PARTICIPANTS AND/OR CONTROLS: Seventy eyes of 70 patients with age ranging from 49 to 92 years, scheduled for cataract surgery, were included.
All subjects underwent a complete ophthalmological examination, including ART-OCT volume with Heidelberg Spectralis before and approximately one month later cataract surgery.
The macula was divided into a central foveal region and four parafoveal regions (superior, inferior, nasal, temporal). The scans were then automatically segmented into the different retinal layers and the changes in each layer were assessed.
The results revealed that both the inner retinal layers and the entire retina exhibited a statistically significant thickening in foveal and parafoveal region: IRL ( < 0.001), ONL ( < 0.001), GCL ( = 0.010), RNFL ( = 0.020), and ALL ( < 0.001). Conversely, the outer retinal layers showed a statistically significant reduction in thickness only within the parafoveal regions: ORL ( < 0.001).
This study may provide a pathophysiological explanation for post-phacoemulsification changes affecting the retina.
由于白内障超声乳化术后眼底变化的确切机制尚未完全阐明，本研究旨在检测白内障手术对视网膜各层厚度的短期影响。
一项回顾性观察研究。
纳入70例年龄在49至92岁之间计划行白内障手术患者的70只眼。
所有受试者均接受了全面的眼科检查，包括在白内障手术前及术后约1个月使用海德堡Spectralis进行ART-OCT容积扫描。
黄斑区分为中央凹区域和四个旁中央凹区域（上方、下方、鼻侧、颞侧）。然后将扫描图像自动分割为不同的视网膜层，并评估各层的变化。
结果显示，视网膜内层和整个视网膜在中央凹和旁中央凹区域均出现统计学上显著增厚：内层视网膜（<0.001）、外层神经上皮层（<0.001）、神经节细胞层（=0.010）、视网膜神经纤维层（=0.020）和全层（<0.001）。相反，外层视网膜仅在旁中央凹区域厚度出现统计学上显著减小：外层视网膜（<0.001）。
本研究可能为白内障超声乳化术后影响视网膜的变化提供病理生理学解释。
