Kaminskaia G O, Abdullaev R Iu, Baturova G A, Komissarova O G
Tuberk Biolezni Legkih. 2009(7):46-55.
Two hundred and forty-three patients with different forms of active pulmonary tuberculosis were examined. The iron intake was estimated by the serum iron (SI) concentrations, total iron-binding capacity (TIBC), unsaturated iron-binding capacity, transferring iron saturation factor (SF), and ferritin (FT) levels. The findings were compared with the values of red blood cells and the systemic inflammatory response assessed from the levels of acute phase reactants (APR). The obtained results were assessed, comparing with the normal range of values separately in male and female patients. Reductions in SI concentrations and TIBC were found to be typical of patients with active tuberculosis. These changes are the components of a systemic inflammatory response and associated with the development of hypochromic anemia. FT, as an ARR, shows heterodirectional changes. The reduction in this index in female patients with pulmonary tuberculosis frequently indicates their susceptibility to the development of true SI deficiency. In males, FT mainly behaves as an APR, which hinders the clarification of the nature of hypochromic anemia. The levels of SI and SF become normal during effective treatment while ineffective treatment deteriorates hypoferremia.
对243例不同类型的活动性肺结核患者进行了检查。通过血清铁（SI）浓度、总铁结合力（TIBC）、不饱和铁结合力、转铁蛋白铁饱和度因子（SF）和铁蛋白（FT）水平来评估铁摄入量。将这些结果与红细胞值以及根据急性期反应物（APR）水平评估的全身炎症反应进行比较。将所得结果与男性和女性患者各自的正常参考值范围进行比较评估。发现活动性肺结核患者典型地存在SI浓度和TIBC降低的情况。这些变化是全身炎症反应的组成部分，并与低色素性贫血的发生有关。作为一种急性期反应物，FT呈现出不同方向的变化。肺结核女性患者该指标的降低常常表明她们易发生真正的SI缺乏。在男性中，FT主要表现为一种急性期反应物，这不利于阐明低色素性贫血的本质。在有效治疗期间，SI和SF水平恢复正常，而无效治疗则会使低铁血症恶化。
