Svensson L
Department of Pharmacology, University of Göteborg, Sweden.
Eur J Pharmacol. 1990 Jan 3;175(1):107-11. doi: 10.1016/0014-2999(90)90160-8.
The (+) and (-) isomers of 3-(3-hydroxyphenyl)-N-propylpiperidine (3-PPP) (2-32 mg/kg) were tested for their effects on the acoustic startle response in the rat and these effects were compared with those of apomorphine and haloperidol. Both startle amplitude and startle latency were recorded. (+)-3-PPP produced a dose-dependent prolongation of startle latency. No other significant effects of the 3-PPP isomers were observed. Apomorphine (0.75-3 mg/kg) produced a dose-dependent increase in startle amplitude concurrent with a dose-dependent prolongation of startle latency. Both these effects were blocked by haloperidol. Haloperidol by itself produced a significant decrease in startle amplitude at the highest dose used (1.6 mg/kg). These and other data suggest that activation of both dopamine D-1 and dopamine D-2 receptors is essential for the stimulatory effects of dopamine receptor agonists on the acoustic startle response in the rat.
对3-(3-羟基苯基)-N-丙基哌啶（3-PPP）的(+)和(-)异构体（2-32毫克/千克）进行了测试，观察它们对大鼠听觉惊吓反应的影响，并将这些影响与阿扑吗啡和氟哌啶醇的影响进行比较。记录了惊吓幅度和惊吓潜伏期。(+)-3-PPP使惊吓潜伏期呈剂量依赖性延长。未观察到3-PPP异构体的其他显著影响。阿扑吗啡（0.75-3毫克/千克）使惊吓幅度呈剂量依赖性增加，同时使惊吓潜伏期呈剂量依赖性延长。这两种效应均被氟哌啶醇阻断。氟哌啶醇本身在所用最高剂量（1.6毫克/千克）时使惊吓幅度显著降低。这些及其他数据表明，多巴胺D-1和多巴胺D-2受体的激活对于多巴胺受体激动剂对大鼠听觉惊吓反应的刺激作用至关重要。
