Davis M, Aghajanian G K
Psychopharmacology (Berl). 1976 Jun 23;47(3):217-23. doi: 10.1007/BF00427605.
A series of 3 experiments tested the effects of 0.01, 0.04, 0.19, 0.75, 3.00, and 6.00 mg/kg apomorphine and 0.13, 0.25, and 0.50 haloperidol on the acoustic startle response in rats. Apomorphine markedly facilitated startle amplitude for about 40 min after injection and then depressed startle over the next 40 min. Both the early facilitory and later inhibitory effects were directly related to the dose. Haloperidol (0.5 mg/kg--given 30 min before) completely blocked both the early facilitory and the later depressant effect of apomorphine (3 mg/kg). Haloperidol alone had only a slight depressant effect on startle. The data support the conclusion that DA receptor stimulation enhances acoustic startle amplitude and indicate that a previous report failed to find an effect of apomorphine on startle because startle was only measured 40 min after injection.
一系列3个实验测试了0.01、0.04、0.19、0.75、3.00和6.00毫克/千克阿扑吗啡以及0.13、0.25和0.50毫克氟哌啶醇对大鼠听觉惊跳反应的影响。阿扑吗啡在注射后约40分钟显著促进惊跳幅度，然后在接下来的40分钟内抑制惊跳。早期促进作用和后期抑制作用均与剂量直接相关。氟哌啶醇（0.5毫克/千克，在注射前30分钟给予）完全阻断了阿扑吗啡（3毫克/千克）的早期促进作用和后期抑制作用。单独使用氟哌啶醇对惊跳只有轻微的抑制作用。这些数据支持多巴胺受体刺激增强听觉惊跳幅度的结论，并表明先前的一份报告未能发现阿扑吗啡对惊跳的影响，是因为仅在注射后40分钟测量了惊跳。
