Vij U, Murugesan K, Laumas K R, Farooq A
Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi.
Int J Gynaecol Obstet. 1990 Apr;31(4):347-53. doi: 10.1016/0020-7292(90)90913-6.
Progesterone receptors (PRs) in human fibromyomata (myomas) and normal myometrium were characterized by gel filtration, sucrose gradient sedimentation analysis, isoelectrofocusing and ligand specificity. The PR population in myoma tissues, 1242 +/- 505 fmol/mg protein, was 3-fold higher than normal myometrial tissues under similar hormonal milieu. The increased PR concentration in myomas appears to be of potential importance in physiopathology of fibromyoma.
通过凝胶过滤、蔗糖梯度沉降分析、等电聚焦和配体特异性对人纤维瘤（肌瘤）和正常子宫肌层中的孕酮受体（PRs）进行了表征。在相似的激素环境下，肌瘤组织中的PR总量为1242±505 fmol/mg蛋白质，比正常子宫肌层组织高3倍。肌瘤中PR浓度的增加在纤维瘤的生理病理学中似乎具有潜在重要性。
