Eur Psychiatry. 1998 Dec;13(8):407-10. doi: 10.1016/S0924-9338(99)80687-7.
Two X-linked microsatellites, (AC)n repeats at the monoamine oxidase (MAO) A locus and (TG)n repeats at the MAO-B locus, were typed by using a PCR-based procedure in 89 nuclear families consisting of mothers, fathers and female affected offspring with schizophrenia or mothers and male affected offspring. A haplotype-based haplotype relative risk (HHRR) approach was applied to detect allelic association of these two microsatellites with schizophrenia. In the families of male patients, a significant difference in frequency distribution was found between transmitted and non-transmitted (TG)n repeats (chi(2) = 15.13, df = 6, P = 0.019), and Fisher's exact test showed that allelic frequency of the transmitted (TG)(24) was significantly higher than that of the non-transmitted (TG)(24) (Fisher's P = 0.003). However, no significant differences in frequency distribution between mother- or father-transmitted and non-transmitted (TG)n repeats were found in the families of female patients. No significant differences in frequency distribution were found between transmitted and non-transmitted (AC)n repeats in the families of either male patients or female patients. The present study suggests that the MAO-B gene may be associated with schizophrenia, and the underlying genetic mechanism of schizophrenia may differ between male and female schizophrenic individuals.
两个 X 连锁微卫星，（AC）n 重复在单胺氧化酶（MAO）A 基因座和（TG）n 重复在 MAO-B 基因座，通过使用基于 PCR 的程序在 89 个核家族中进行了分型，这些核家族由患有精神分裂症的母亲、父亲和女性受影响的后代，以及患有精神分裂症的母亲和男性受影响的后代组成。采用基于单体型的单体型相对风险（HHRR）方法检测这两个微卫星与精神分裂症的等位基因关联。在男性患者的家庭中，传递和非传递（TG）n 重复之间的频率分布存在显著差异（chi(2) = 15.13，df = 6，P = 0.019），Fisher 确切检验表明，传递的（TG）（24）等位基因频率明显高于非传递的（TG）（24）（Fisher 的 P = 0.003）。然而，在女性患者的家庭中，母系或父系传递和非传递（TG）n 重复之间的频率分布没有显著差异。在男性或女性患者的家庭中，传递和非传递（AC）n 重复之间的频率分布没有显著差异。本研究表明 MAO-B 基因可能与精神分裂症有关，男性和女性精神分裂症个体的潜在遗传机制可能不同。
