Mole R H
Int J Radiat Biol. 1990 Apr;57(4):647-63. doi: 10.1080/09553009014550831.
Recently reported dose responses in prenatally exposed Japanese bomb survivors for severe mental retardation (SMR), reduced intelligence, and reduced levels of school performance, are compared. The characteristics of, and differences between, severe and mild mental retardation in man are critically important for such comparisons. The meaning of linearity of dose response is not identical for these different forms of damage. When findings on tissue changes in the brain and in functional tests of irradiated experimental animals are taken into account, the dose response for SMR would be expected to have a threshold as is found using DS86 dosimetry. The dose responses for IQ and for school performance seem doubtfully valid: their underlying assumptions need re-examination.
本文比较了近期报道的日本原子弹爆炸幸存者产前暴露后出现严重智力迟钝（SMR）、智力下降和学业成绩水平降低的剂量反应。人类中重度和轻度智力迟钝的特征及差异对于此类比较至关重要。剂量反应的线性对于这些不同形式的损伤而言含义并不相同。当考虑到辐照实验动物大脑组织变化及功能测试的结果时，使用DS86剂量测定法发现，预计SMR的剂量反应会有一个阈值。智商和学业成绩的剂量反应似乎有效性存疑：其潜在假设需要重新审视。
