Broom Kerry A, Findlay Richard, Addison Darren S, Goiceanu Cristian, Sienkiewicz Zenon
Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Oxfordshire, UK.
Physics Group, EMFcomp Limited, Harwell Campus, Harwell, Oxfordshire, UK.
Bioelectromagnetics. 2019 Oct;40(7):498-511. doi: 10.1002/bem.22217. Epub 2019 Sep 15.
Despite much research, gaps remain in knowledge about the potential health effects of exposure to radiofrequency (RF) fields. This study investigated the effects of early-life exposure to pulsed long term evolution (LTE) 1,846 MHz downlink signals on innate mouse behavior. Animals were exposed for 30 min/day, 5 days/week at a whole-body average specific energy absorption rate (SAR) of 0.5 or 1 W/kg from late pregnancy (gestation day 13.5) to weaning (postnatal day 21). A behavioral tracking system measured locomotor, drinking, and feeding behavior in the home cage from 12 to 28 weeks of age. The exposure caused significant effects on both appetitive behaviors and activity of offspring that depended on the SAR. Compared with sham-exposed controls, exposure at 0.5 W/kg significantly decreased drinking frequency (P ≤ 0.000) and significantly decreased distance moved (P ≤ 0.001). In contrast, exposure at 1 W/kg significantly increased drinking frequency (P ≤ 0.001) and significantly increased moving duration (P ≤ 0.005). In the absence of other plausible explanations, it is concluded that repeated exposure to low-level RF fields in early life may have a persistent and long-term effect on adult behavior. Bioelectromagnetics. 2019;40:498-511. © 2019 The Authors. Bioelectromagnetics Published by Wiley Periodicals, Inc.
尽管进行了大量研究，但在射频（RF）场暴露对健康的潜在影响方面，仍存在知识空白。本研究调查了生命早期暴露于脉冲长期演进（LTE）1846兆赫下行链路信号对小鼠先天行为的影响。从妊娠晚期（妊娠第13.5天）到断奶（出生后第21天），动物每天暴露30分钟，每周5天，全身平均比吸收率（SAR）为0.5或1瓦/千克。一个行为跟踪系统测量了12至28周龄在家笼中的运动、饮水和进食行为。暴露对后代的食欲行为和活动产生了显著影响，这取决于比吸收率。与假暴露对照组相比，0.5瓦/千克的暴露显著降低了饮水频率（P≤0.000），并显著减少了移动距离（P≤0.001）。相比之下，1瓦/千克的暴露显著增加了饮水频率（P≤0.001），并显著增加了移动持续时间（P≤0.005）。在没有其他合理的解释的情况下，可以得出结论，生命早期反复暴露于低水平射频场可能会对成年行为产生持续的长期影响。《生物电磁学》。2019年；40：498 - 511。©2019作者。《生物电磁学》由威利期刊公司出版。
