Twist在不同亚型成釉细胞瘤中的表达。
Expression of Twist in different subtype of ameloblastomas.
作者信息
Feng Yang, Zhou Yin-Mei, Hua Cheng-Ge, Tang Xiu-Fa, He Deng-Qi
机构信息
State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Sichuan, People's Republic of China.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Oct;108(4):565-70. doi: 10.1016/j.tripleo.2009.05.041. Epub 2009 Aug 20.
OBJECTIVE
The objective of this study was to investigate the pattern of Twist expression in a series of ameloblastomas, and to study the possible role of Twist in the bone destruction and local invasiveness of ameloblastoma variants.
STUDY DESIGN
Immunohistochemical study was performed for Twist protein in 53 ameloblastomas (32 solid/multicystic [SA] and 21 unicystic [UA]).
RESULTS
The salient finding was that expression of Twist was related to the histological subtype of tumors, as there was a higher expression in SA (14/32, 43.75%) as compared to UA (4/21, 19.05%) (P < .05). Both nuclei and cytoplasm positivities were detected in positive cases, whereas cytoplasmic staining was diffused and predominant. Cases rich in stromal cells showed a higher percentage of positive cells than those with less stroma.
CONCLUSIONS
Our results suggest that Twist expression might be associated with invasion in ameloblastoma variants, and stromal cells might play a regulatory role during tumor development.
目的
本研究的目的是调查一系列成釉细胞瘤中Twist的表达模式，并研究Twist在成釉细胞瘤变异型的骨质破坏和局部侵袭中可能发挥的作用。
研究设计
对53例成釉细胞瘤（32例实性/多囊性[SA]和21例单囊性[UA]）进行Twist蛋白的免疫组织化学研究。
结果
显著发现是Twist的表达与肿瘤的组织学亚型相关，因为与UA（4/21，19.05%）相比，SA中Twist的表达更高（14/32，43.75%）（P <.05）。在阳性病例中检测到细胞核和细胞质均呈阳性，而细胞质染色呈弥漫性且为主。富含基质细胞的病例阳性细胞百分比高于基质较少的病例。
结论
我们的结果表明，Twist表达可能与成釉细胞瘤变异型的侵袭有关，并且基质细胞可能在肿瘤发展过程中发挥调节作用。
Zotero 插件