Kostov Konstantin, Kostov Hrisimir, Taubøll Erik
National Centre for Epilepsy, Division of Clinical Neuroscience, Oslo University Hospital-Rikshospitalet, Oslo, Norway.
Epilepsy Behav. 2009 Oct;16(2):321-4. doi: 10.1016/j.yebeh.2009.07.038. Epub 2009 Aug 20.
The long-term effects of vagus nerve stimulation (VNS) on seizure frequency were studied in 30 patients with Lennox-Gastaut syndrome. Median observation time was 52 months (17-123). The effect parameters investigated were total number of seizures and different seizure types. The median reduction in number of seizures was 60.6%. The effects of VNS varied considerably between seizure types. Best effects were observed with atonic seizures (80.8% median reduction, number of responders: 8/12), followed closely by tonic seizures (73.3% median reduction, number of responders: 8/13). Least effects were with generalized tonic-clonic seizures (median reduction 57.4%, number of responders: 11/20). Additional positive effects included milder or shorter ictal or postictal phase in 16 patients. Improved alertness was reported in 76.7%. Adverse effects, of which drooling and voice alteration were most frequent, were reported in 20 patients. There was a statistically significant reduction in the median number of antiepileptic drugs used. The discontinuation rate was 16.7%.
对30例Lennox-Gastaut综合征患者研究了迷走神经刺激（VNS）对癫痫发作频率的长期影响。中位观察时间为52个月（17 - 123个月）。所研究的效应参数为癫痫发作总数和不同发作类型。癫痫发作次数的中位数减少了60.6%。VNS的效果在不同发作类型之间差异很大。失张力发作的效果最佳（中位数减少80.8%，有效者数量：8/12），其次是强直发作（中位数减少73.3%，有效者数量：8/13）。全身强直阵挛发作的效果最差（中位数减少57.4%，有效者数量：11/20）。其他积极效果包括16例患者的发作期或发作后期症状减轻或持续时间缩短。76.7%的患者报告警觉性提高。20例患者报告了不良反应，其中流涎和声音改变最为常见。使用的抗癫痫药物中位数有统计学显著减少。停药率为16.7%。
