John Shinu A, Garrett-Sinha Lee Ann
Department of Biochemistry, Center for Excellence in Bioinformatics and Life Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA.
Exp Cell Res. 2009 Apr 15;315(7):1077-84. doi: 10.1016/j.yexcr.2008.11.015. Epub 2008 Dec 3.
B lymphocyte induced maturation protein 1 (Blimp1) is a zinc finger transcriptional repressor whose function as a master regulator of terminal differentiation of B cells into plasma cells has long been studied and is well established. Recent studies have identified novel roles for Blimp1 including homeostasis of effector T cells, specification of primordial germ cells in mouse, specification of muscle fiber type in zebrafish and as a tumor suppressor gene in germinal center derived B cells. Blimp1 associates with a multitude of chromatin modifying enzymes inducing epigenetic changes at specific targets to regulate these diverse cell fates. In this review, we focus on the novel and emerging roles of Blimp1 in multiple tissues, on mechanisms of transcriptional repression by Blimp1 and on the activity of Blimp1 as a tumor suppressor.
B淋巴细胞诱导成熟蛋白1（Blimp1）是一种锌指转录抑制因子，长期以来，其作为B细胞终末分化为浆细胞的主要调节因子的功能一直是研究热点且已得到充分证实。最近的研究发现了Blimp1的新作用，包括效应T细胞的稳态维持、小鼠原始生殖细胞的特化、斑马鱼肌纤维类型的特化以及作为生发中心来源B细胞中的肿瘤抑制基因。Blimp1与多种染色质修饰酶结合，在特定靶点诱导表观遗传变化，以调节这些不同的细胞命运。在本综述中，我们重点关注Blimp1在多种组织中的新作用和新兴作用、Blimp1的转录抑制机制以及Blimp1作为肿瘤抑制因子的活性。
