Clinical Neuroscience, St George's University of London, Cranmer Terrace, London SW17 0RE, UK.
Neuropsychologia. 2010 Jan;48(1):114-22. doi: 10.1016/j.neuropsychologia.2009.08.018.
It has been proposed that episodic long-term memory (LTM) declines in normal aging and may be affected by disruption of white matter networks. This was explored in 104 healthy adults aged 50-90 years in the GENIE study; white matter integrity was assessed using diffusion tensor imaging (DTI) in large regions of interest, with additional measures of white matter hyperintensities (WMH), normalized brain and hippocampal volumes. LTM was compared with executive function, working memory and information processing speed. LTM correlated significantly with DTI, WMH and whole brain volume, but not with hippocampal volume. Using linear regression, only DTI measures explained the variance (approximately 19%) in LTM; mediational analyses explored the extent to which other cognitive functions mediate the association between DTI changes and memory. The results suggest that reduced LTM performance in normal aging is related to reduced integrity of a distributed network dependent on white matter pathways supporting episodic memory.
有人提出，在正常衰老过程中，情景式长时记忆（LTM）会衰退，并且可能会受到白质网络中断的影响。这项研究在 GENIE 研究中对 104 名 50-90 岁的健康成年人进行了探索；使用弥散张量成像（DTI）对大感兴趣区域的白质完整性进行评估，并对白质高信号（WMH）、大脑和海马体体积进行了归一化测量。LTM 与执行功能、工作记忆和信息处理速度进行了比较。LTM 与 DTI、WMH 和全脑体积显著相关，但与海马体体积无关。使用线性回归，只有 DTI 测量解释了 LTM 的方差（约 19%）；中介分析探讨了其他认知功能在多大程度上调节了 DTI 变化与记忆之间的关联。研究结果表明，在正常衰老过程中，LTM 表现下降与依赖于支持情景记忆的白质通路的分布式网络的完整性降低有关。
