Kihampa Charles, Nkunya Mayunga H H, Joseph Cosam C, Magesa Stephen M, Hassanali Ahmed, Heydenreich Matthias, Kleinpeter Erich
Department of Environmental Science and Management, Ardhi University, P.O. Box 35176, Dar es Salaam, Tanzania.
Phytochemistry. 2009 Jul;70(10):1233-8. doi: 10.1016/j.phytochem.2009.07.024. Epub 2009 Aug 21.
The nor-halimane diterpenoid tessmannic acid and its methyl, 2-methylisopropyl and 1-methylbutyl esters, the unusual isocoumarins 8-hydroxy-6-methoxy-3-pentylisocoumarin and 7-chloro-8-hydroxy-6-methoxy-3-pentylisocoumarin, and 5-pentyl-3-methoxy-N-butylaniline were isolated from the stem and root bark extracts of Tessmannia densiflora Harms (Caesalpiniaceae) that showed mosquito larvicidal activity. The structures were determined on interpretation of spectroscopic data. Tessmannic acid and its methyl ester exhibited antibacterial and antifungal activity. The compounds also caused high larvae and adult Anopheles gambiae mosquitoe mortality effects, and stronger mosquito repellency than that shown by the standard repellent DEET, hence indicating Tessmannia species to be potential sources of bioactive natural products.
从密花特斯曼木（豆科）的茎和根皮提取物中分离出降海松烷二萜类化合物特斯曼酸及其甲酯、2-甲基异丙酯和1-甲基丁酯、不寻常的异香豆素8-羟基-6-甲氧基-3-戊基异香豆素和7-氯-8-羟基-6-甲氧基-3-戊基异香豆素，以及5-戊基-3-甲氧基-N-丁基苯胺，这些提取物具有杀蚊幼虫活性。通过光谱数据解释确定了其结构。特斯曼酸及其甲酯具有抗菌和抗真菌活性。这些化合物还对冈比亚按蚊幼虫和成虫产生了较高的致死作用，并且驱蚊性比标准驱蚊剂避蚊胺更强，因此表明特斯曼木属植物是生物活性天然产物的潜在来源。
