Daniel Alexandre G T, Lucas Sílvia R R, Júnior Archivaldo R, Monteiro Paula R G, Ramos Daniela, Pires Carolina G, Sinhorini Idércio L
College of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, Brazil.
J Feline Med Surg. 2010 Feb;12(2):151-5. doi: 10.1016/j.jfms.2009.07.006. Epub 2009 Aug 22.
A case of acquired skin fragility syndrome associated with hepatic disease in a 9-year-old, spayed female, domestic shorthair cat is described. The cat was admitted to the veterinary hospital of the University of São Paulo (Brazil) with a 6-week history of vomiting, inappetence and weight loss. Remarkable signs were weakness, lethargy and profound jaundice that had been present for 10 days according to the owner. On completion of the physical examination, when the cat was gently manipulated for blood collection the thoracic limb and interscapular skin tore. Liver enzymes and bilirubin levels were all above the normal range. On histological examination of skin and liver, Masson's trichrome stain showed collagen fibre alteration and major hepatocyte abnormalities. Findings were consistent with feline skin fragility syndrome associated with cholangiohepatitis and hepatic lipidosis.
描述了一例9岁已绝育雌性家养短毛猫患获得性皮肤脆弱综合征并伴有肝脏疾病的病例。这只猫因有6周呕吐、食欲不振和体重减轻的病史而被收治于巴西圣保罗大学兽医院。显著体征为虚弱、嗜睡以及据主人描述已持续10天的深度黄疸。体格检查完成后，当轻轻操作这只猫进行采血时，其胸肢和肩胛间皮肤撕裂。肝酶和胆红素水平均高于正常范围。对皮肤和肝脏进行组织学检查时，马松三色染色显示胶原纤维改变以及主要的肝细胞异常。这些发现与猫皮肤脆弱综合征伴胆管肝炎和肝脂质沉积相符。
