Institut für Umweltmedizinische Forschung, Auf'm Hennekamp 50, 40225 Düsseldorf, Germany.
Trends Immunol. 2009 Sep;30(9):447-54. doi: 10.1016/j.it.2009.06.005. Epub 2009 Aug 21.
Low-molecular-weight chemicals or xenobiotics might contribute to the increasing prevalence of allergies and autoimmunity. Certain chemicals can alter immune responses via their action on the cytosolic transcription factor aryl hydrocarbon receptor (AhR). AhR recognizes numerous small xenobiotic and natural molecules, such as dioxin and the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole. Although AhR is best known for mediating dioxin toxicity, knockout studies have indicated that AhR also plays a role in normal physiology, including certain immune responses. In particular, Th17 cells and dendritic cells express high levels of AhR. We review here current evidence for the physiological role of AhR in the immune system, focussing in particular on T-cell biology.
低分子量化学物质或外源性化学物质可能导致过敏和自身免疫性疾病的发病率不断上升。某些化学物质可以通过其对胞质转录因子芳香烃受体（AhR）的作用来改变免疫反应。AhR 识别许多小分子外源性化学物质和天然分子，如二恶英和色氨酸光产物 6-甲酰基吲哚[3,2-b]咔唑。虽然 AhR 以介导二恶英毒性而闻名，但敲除研究表明 AhR 也在正常生理中发挥作用，包括某些免疫反应。特别是，Th17 细胞和树突状细胞表达高水平的 AhR。我们在此回顾了 AhR 在免疫系统中的生理作用的现有证据，特别关注 T 细胞生物学。
