Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Trends Immunol. 2009 Sep;30(9):421-9. doi: 10.1016/j.it.2009.06.004. Epub 2009 Aug 21.
ATP-binding cassette (ABC) transporters are known for their involvement in clinical multidrug resistance (MDR) and their physiological defensive functions in barrier organs. More recently, attention has been focused on their possible involvement in the regulation of immune responses following the identification of their substrates as known immunomodulating agents (e.g. prostaglandins, leukotrienes and cyclic nucleotides) and their functional expression in various immune effector cells, most notably in dendritic cells (DCs). This review addresses the possible roles of ABC transporters in DC development and function, as well as the putative immunostimulatory potential of their cytostatic substrates and how this knowledge might benefit DC-based chemo-immunotherapies.
ATP 结合盒（ABC）转运蛋白以其参与临床多药耐药（MDR）和在屏障器官中的生理防御功能而闻名。最近，人们越来越关注它们在调节免疫反应中的可能作用，因为它们的底物被确定为已知的免疫调节剂（例如前列腺素、白三烯和环核苷酸），并且它们在各种免疫效应细胞（尤其是树突状细胞（DCs））中功能性表达。这篇综述探讨了 ABC 转运蛋白在 DC 发育和功能中的可能作用，以及它们细胞抑制性底物的潜在免疫刺激潜力，以及这些知识如何使基于 DC 的化疗免疫疗法受益。
