采用熔融石英毛细管柱气相色谱柱上进样技术同时测定大鼠血浆和尿液中的吗啉酮和苯甲曲秦。
Simultaneous determination of morazone and phenmetrazine in rat plasma and urine using an on-column injection technique with fused-silica capillary column gas chromatography.
作者信息
Lho D, Shin H, Park J
机构信息
Doping Control Center, Korea Institute of Science and Technology, Kangnam-ku, Seoul.
出版信息
J Anal Toxicol. 1990 Mar-Apr;14(2):113-5. doi: 10.1093/jat/14.2.113.
The simultaneous determination of morazone and its major metabolite, phenmetrazine, using an on-column injection technique with fused-silica capillary column gas chromatography is described. The on-column injection technique prevents the decomposition of morazone. The limit of quantitation in 0.1 mL of rat plasma for morazone and phenmetrazine is 5 ng/mL and that in 1.0 mL of rat urine is 1 ng/mL. The within run precisions (%CV) at the concentration of 0.5 micrograms/mL are 3.27% for morazone and 3.09% for phenmetrazine.
本文描述了使用熔融石英毛细管柱气相色谱柱上注射技术同时测定吗啉酮及其主要代谢物苯丙胺的方法。柱上注射技术可防止吗啉酮分解。在0.1 mL大鼠血浆中，吗啉酮和苯丙胺的定量限为5 ng/mL，在1.0 mL大鼠尿液中的定量限为1 ng/mL。在0.5微克/毫升浓度下，吗啉酮的批内精密度（%CV）为3.27%，苯丙胺为3.09%。
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