挪威心力衰竭患者的性别差异。

Gender differences among Norwegian patients with heart failure.

机构信息

Medical Department, Division of Cardiology, Aker University Hospital, Oslo, Norway.

出版信息

Int J Cardiol. 2011 Feb 3;146(3):354-8. doi: 10.1016/j.ijcard.2009.07.014. Epub 2009 Aug 22.

DOI:10.1016/j.ijcard.2009.07.014

PMID:19700210

Abstract

BACKGROUND

Recent studies have suggested differences in outcome and treatment between men and women with heart failure. The aim of this study was to see if there were gender differences in the treatment and outcome in real life heart failure patients.

METHODS

Norwegian Heart Failure Registry was used. Three-thousand-six-hundred-and-thirty-two patients (men, n = 2545 (70%), women, n = 1087 (30%)) were included in the study from January 2000 to February 2006. Patients were followed up until death or December 31 2006. The cohort was split into patients with an ejection fraction (EF) less and above 50% and genders were then compared.

RESULTS

In the group with EF ≥ 50% the only difference between basic characteristics was that men had a lower heart rate. In the group with an EF<50% women were older, had a higher heart rate, had less often atrial fibrillation, were less often smokers and had a more severe NYHA-classification compared to men. More men used statins and warfarin and coronary heart disease (CHD) was more common as the underlying cause of heart failure among men compared to women. In a Kaplan-Meier analysis there was no significant difference between men and women concerning survival.

CONCLUSION

There are differences in basic characteristics, medical history and treatment between men and women in the Norwegian Heart Failure Registry. The survival rates were equal between men and women in this group of real life patients with heart failure.

摘要

背景

最近的研究表明，男性和女性心力衰竭患者的预后和治疗存在差异。本研究旨在观察真实世界心力衰竭患者的治疗和预后是否存在性别差异。

方法

使用挪威心力衰竭注册中心的数据。从 2000 年 1 月至 2006 年 2 月，共纳入 3632 例患者（男性 2545 例[70%]，女性 1087 例[30%]）。患者随访至死亡或 2006 年 12 月 31 日。该队列分为射血分数（EF）<50%和 EF≥50%两组，然后比较性别差异。

结果

EF≥50%组中，基本特征的唯一差异是男性的心率较低。EF<50%组中，女性年龄较大、心率较高、心房颤动较少、吸烟较少、NYHA 心功能分级较严重，与男性相比，心力衰竭的潜在病因中冠心病更为常见。男性更常使用他汀类药物和华法林，冠心病更为常见。在 Kaplan-Meier 分析中，男性和女性的生存率无显著差异。