来自圆齿冷水花亚种的倍半萜类化合物。

Sesquiterpenoids from Pilea cavaleriei subsp. crenata.

作者信息

Tang Gui-Hua, Sun Chang-Song, Long Chun-Lin, Li Ma-Lin, Wang Yue-Hu, Luo Min, Wang Hong-Sheng, Shi Ya-Na

机构信息

Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.

出版信息

Bioorg Med Chem Lett. 2009 Oct 1;19(19):5737-40. doi: 10.1016/j.bmcl.2009.08.001. Epub 2009 Aug 6.

DOI:10.1016/j.bmcl.2009.08.001

PMID:19700322

Abstract

Three new humulane-type sesquiterpenes, 8-O-(p-coumaroyl)-5beta-hydroperoxy-1(10)E,4(15)-humuladien-8alpha-ol (1), 8-O-(3-nitro-p-coumaroyl)-1(10)E,4(15)-humuladien-5beta,8alpha-diol (2) and 8-O-(p-coumaroyl)-1(10)E,4(5)E-humuladien-8-ol (3), and a new copaborneol derivative, 1-O-p-coumaroyl-copaborneol (4), have been isolated from the methanol extract of Pileacavaleriei Lévl. subsp. crenata C. J. Chen. Their structures were elucidated using spectroscopic methods. Cytotoxic and antimicrobial activities of the isolated compounds were evaluated.

摘要

从光叶火炭母（Pileacavaleriei Lévl. subsp. crenata C. J. Chen）的甲醇提取物中分离出三种新的葎草烷型倍半萜，8-O-(对香豆酰基)-5β-氢过氧基-1(10)E,4(15)-葎草二烯-8α-醇（1）、8-O-(3-硝基-对香豆酰基)-1(10)E,4(15)-葎草二烯-5β,8α-二醇（2）和8-O-(对香豆酰基)-1(10)E,4(5)E-葎草二烯-8-醇（3），以及一种新的异龙脑衍生物，1-O-对香豆酰基-异龙脑（4）。通过光谱方法阐明了它们的结构。对分离得到的化合物进行了细胞毒性和抗菌活性评估。