口蹄疫病毒某些温度敏感突变体中存在小鼠致病位点的证据。
Evidence for a mouse pathogenicity locus in certain temperature-sensitive mutants of foot-and-mouth disease virus.
作者信息
Richmond J Y
出版信息
Infect Immun. 1977 Jun;16(3):827-31. doi: 10.1128/iai.16.3.827-831.1977.
Abstract
Serial tissue culture passaging of three foot-and-mouth disease temperature-sensitive mutants demonstrated the stability of their temperature sensitivity and mouse avirulence characteristics. Recovery of mouse-virulent temperature-sensitive viruses after passage of the mutants in mice suggested that these were not covariant expressions of the same locus, but were under the control of different genes.
摘要
对三种口蹄疫温度敏感突变株进行连续的组织培养传代，结果表明它们的温度敏感性和对小鼠无毒力的特性具有稳定性。这些突变株在小鼠体内传代后出现了对小鼠有毒力的温度敏感病毒，这表明这些特性并非同一基因座的协变表达，而是受不同基因的控制。
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