Richmond J Y
Infect Immun. 1977 Jun;16(3):827-31. doi: 10.1128/iai.16.3.827-831.1977.
Serial tissue culture passaging of three foot-and-mouth disease temperature-sensitive mutants demonstrated the stability of their temperature sensitivity and mouse avirulence characteristics. Recovery of mouse-virulent temperature-sensitive viruses after passage of the mutants in mice suggested that these were not covariant expressions of the same locus, but were under the control of different genes.
对三种口蹄疫温度敏感突变株进行连续的组织培养传代,结果表明它们的温度敏感性和对小鼠无毒力的特性具有稳定性。这些突变株在小鼠体内传代后出现了对小鼠有毒力的温度敏感病毒,这表明这些特性并非同一基因座的协变表达,而是受不同基因的控制。