流感病毒温度敏感突变体的毒力
Virulence of temperature-sensitive mutants of influenza virus.
作者信息
Mackenzie J S
出版信息
Br Med J. 1969 Sep 27;3(5673):757-8. doi: 10.1136/bmj.3.5673.757.
Abstract
The acquisition of temperature-mutant (ts) defects in a strain of influenza virus has been shown in mice to be associated with diminished virulence, though the antibody-producing stimulus remained. It is suggested that three advantages may make ts strains potential sources of attenuated live influenza vaccine-the ease of obtaining the strains, the ease of testing the vaccine strain, and the high yield of vaccine doses from a single egg.
摘要
在小鼠身上已表明，一株流感病毒获得温度突变（ts）缺陷与毒力减弱有关，尽管产生抗体的刺激依然存在。有人提出，ts毒株可能成为减毒活流感疫苗潜在来源有三个优势——易于获得毒株、易于检测疫苗毒株以及从单个鸡蛋中可大量生产疫苗剂量。
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本文引用的文献
1
2
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3
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