用副流感3型病毒的温度敏感（ts）突变株接种仓鼠。
Inoculation of hamsters with a temperature sensitive (ts) mutant of parainfluenza 3 virus.
作者信息
Zygraich N, Lobmann M, Huygelen C
出版信息
J Hyg (Lond). 1972 Jun;70(2):229-34. doi: 10.1017/s0022172400022282.
Abstract
The multiplication pattern of a temperature-sensitive (ts) mutant of bovine parainfluenza 3 virus was studied in hamsters and compared with that of a virulent virus strain. The ts mutant was recovered regularly from the nasal mucosa and not from the lungs, whereas the virulent virus multiplied in the lungs as well as in the nasal mucosa.The serological response induced by the mutant was comparable to that obtained after inoculation of the virulent virus.This ts mutant may be a potential candidate for a live intranasal vaccine against bovine parainfluenza 3 infection.
摘要
研究了牛副流感3病毒温度敏感（ts）突变株在仓鼠中的增殖模式，并与强毒株进行了比较。ts突变株能定期从鼻黏膜中分离出来，但不能从肺中分离出来，而强毒株在肺和鼻黏膜中均能增殖。该突变株诱导的血清学反应与接种强毒株后获得的反应相当。这种ts突变株可能是一种用于预防牛副流感3感染的鼻内活疫苗的潜在候选株。
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