Taha Doris, Ahmed Omaima, bin Sadiq Bakr
Department of Pediatrics, King Faisal Specialist Hospital and Research Centre, PO Box 40047, Jeddah 21499, Saudi Arabia.
Ann Saudi Med. 2009 Sep-Oct;29(5):357-60. doi: 10.4103/0256-4947.55164.
We assessed the distribution of risk factors associated with the metabolic syndrome in a group of obese Saudi children and adolescents. No previous studies had addressed this issue in the Saudi pediatric population.
We retrospectively reviewed the medical records of patients evaluated for obesity between 2004 and 2008 and collected data on age, weight, height, body mass index (BMI), BP, fasting lipid profile, fasting glucose, insulin concentrations, and insulin resistance based on the homeostasis assessment model-insulin resistance (HOMA-IR) score. Obesity was defined as a BMI above the 95th percentile for age and gender and metabolic syndrome was diagnosed according to standard criteria.
We studied 57 obese Saudi children and adolescents with a mean (standard deviation) age of 9.8 (3.5) years. Mean weight and body mass index (BMI) were 63.7 (28.3) kg and 31.6 (8.0) kg/m(2) , respectively. Systolic BP was elevated in 24 (42%) of the 57 subjects. Of the 39 children who had a lipid profile in their records, 10 had hypertriglyceridemia, 8 had hypercholesterolemia, 6 had elevated LDL cholesterol levels, and 6 had low HDL cholesterol levels. Impaired fasting glucose was found in 10 of 38 patients in which it was measured, and 9 of 25 patients had fasting hyperinsulinemia. Eleven of 37 patients (29.7%) met the diagnosis of the metabolic syndrome. Diastolic BP correlated positively with BMI (r=0.440, P =.001), and HDL cholesterol correlated negatively with weight and BMI (r=-0.487, P =.002 and r=-0.317, P =.05). HOMA-IR correlated positively with BMI and triglyceride levels and negatively with HDL cholesterol levels.
Obese Saudi children and adolescents have multiple risk factors associated with metabolic syndrome.
我们评估了一组肥胖沙特儿童和青少年中与代谢综合征相关的危险因素分布情况。此前尚无研究针对沙特儿科人群的这一问题展开探讨。
我们回顾性分析了2004年至2008年间因肥胖接受评估的患者的病历，收集了年龄、体重、身高、体重指数（BMI）、血压、空腹血脂谱、空腹血糖、胰岛素浓度以及基于稳态模型评估胰岛素抵抗（HOMA-IR）评分的胰岛素抵抗数据。肥胖定义为BMI高于年龄和性别的第95百分位数，代谢综合征则根据标准标准进行诊断。
我们研究了57名肥胖沙特儿童和青少年，平均（标准差）年龄为9.8（3.5）岁。平均体重和体重指数（BMI）分别为63.7（28.3）千克和31.6（8.0）千克/平方米。57名受试者中有24名（42%）收缩压升高。在有血脂谱记录的39名儿童中，10名有高甘油三酯血症，8名有高胆固醇血症，6名低密度脂蛋白胆固醇水平升高，6名高密度脂蛋白胆固醇水平降低。在38名进行空腹血糖检测的患者中，10名出现空腹血糖受损，25名患者中有9名出现空腹高胰岛素血症。37名患者中有11名（29.7%）符合代谢综合征诊断。舒张压与BMI呈正相关（r = 0.440，P = 0.001），高密度脂蛋白胆固醇与体重和BMI呈负相关（r = -0.487，P = 0.002和r = -0.317，P = 0.05）。HOMA-IR与BMI和甘油三酯水平呈正相关，与高密度脂蛋白胆固醇水平呈负相关。
肥胖的沙特儿童和青少年存在多种与代谢综合征相关的危险因素。
