Department XI of Pediatrics-1st Pediatric Discipline, Center for Research on Growth and Developmental Disorders in Children, 'Victor Babeș' University of Medicine and Pharmacy Timișoara, Eftimie Murgu Sq no. 2, 300041 Timișoara, Romania.
1st Pediatric Clinic, 'Louis Țurcanu' Children's Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timișoara, Romania.
Nutrients. 2022 Jan 2;14(1):204. doi: 10.3390/nu14010204.
Small and large birth weights (BWs) for gestational age (GA) represent extremes, but the correlation between extreme BW and metabolic syndrome (MetS) has not been fully elucidated. In this study, we examined this correlation in obese children based on changes in their metabolic profile from childhood to adolescence. A retrospective observational study was performed on 535 obese patients aged 0-18 years in the Clinical and Emergency Hospital for Children "Louis Turcanu" in Timisoara, Romania, based on clinical and biological data from January 2015 to December 2019. We emphasized the links between extreme BW and obesity, extreme BW and cardiometabolic risk, obesity and cardiometabolic risk, and extreme BW, obesity and MetS. Children born large for gestational age (LGA) predominated over those born small for gestational age (SGA). Our findings showed that BW has an independent effect on triglycerides and insulin resistance, whereas obesity had a direct influence on hypertension, impaired glucose metabolism and hypertriglyceridemia. The influences of BW and obesity on the development of MetS and its components are difficult to separate; therefore, large prospective studies in normal-weight patients are needed.
小和大出生体重（BW）与胎龄（GA）相关，但极端 BW 与代谢综合征（MetS）之间的相关性尚未完全阐明。本研究基于肥胖儿童从儿童期到青春期代谢特征的变化，检查了这一相关性。在罗马尼亚蒂米什瓦拉的“Louis Turcanu”临床急诊儿童医院，对 2015 年 1 月至 2019 年 12 月期间的 535 名肥胖患者进行了回顾性观察性研究，基于临床和生物学数据。我们强调了极端 BW 与肥胖、极端 BW 与心脏代谢风险、肥胖与心脏代谢风险以及极端 BW、肥胖和 MetS 之间的联系。大于胎龄儿（LGA）比小于胎龄儿（SGA）更为常见。我们的研究结果表明，BW 对甘油三酯和胰岛素抵抗有独立影响，而肥胖对高血压、葡萄糖代谢受损和高三酰甘油血症有直接影响。BW 和肥胖对 MetS 及其成分发展的影响难以分离，因此需要在正常体重患者中进行大规模前瞻性研究。
