缝隙连接通讯在健康和疾病中的机制。
Mechanisms of gap junction traffic in health and disease.
机构信息
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
出版信息
J Cardiovasc Pharmacol. 2009 Oct;54(4):263-72. doi: 10.1097/FJC.0b013e3181ba0811.
Abstract
Gap junctions (GJs) allow direct communication between cells. In the heart, GJs mediate the electrical coupling of cardiomyocytes and as such dictate the speed and direction of cardiac conduction. A prominent feature of acquired structural heart disease is remodeling of GJ protein expression and localization concomitant with increased susceptibility to lethal arrhythmias, leading many to hypothesize that the two are causally linked. Detailed understanding of the cellular mechanisms that regulate GJ localization and function within cardiomyocytes may therefore uncover potential therapeutic strategies for a significant clinical problem. This review will outline our current understanding of GJ cell biology with the intent of highlighting cellular mechanisms responsible for GJ remodeling associated with cardiac disease.
摘要
缝隙连接（GJ）允许细胞之间直接通讯。在心脏中，GJ 介导心肌细胞的电偶联，从而决定心脏传导的速度和方向。获得性结构性心脏病的一个显著特征是 GJ 蛋白表达和定位的重塑，同时增加了致命性心律失常的易感性，这使得许多人假设这两者是因果关系。因此，深入了解调节心肌细胞中 GJ 定位和功能的细胞机制，可能会为这一重大临床问题揭示潜在的治疗策略。本综述将概述我们目前对 GJ 细胞生物学的理解，旨在强调与心脏疾病相关的 GJ 重塑的细胞机制。
相似文献
1
Mechanisms of gap junction traffic in health and disease.
J Cardiovasc Pharmacol. 2009 Oct;54(4):263-72. doi: 10.1097/FJC.0b013e3181ba0811.
2
Douglas P. Zipes Lecture. Biology and pathobiology of cardiac connexins: from cell to bedside.
Heart Rhythm. 2006 Jan;3(1):102-7. doi: 10.1016/j.hrthm.2005.10.021.
3
The amino terminal domain plays an important role in transjunctional voltage-dependent gating kinetics of Cx45 gap junctions.
J Mol Cell Cardiol. 2020 Jun;143:71-84. doi: 10.1016/j.yjmcc.2020.04.004. Epub 2020 Apr 21.
4
[Remodeling of cardiac gap junctions and arrhythmias].
Sheng Li Xue Bao. 2011 Dec 25;63(6):586-92.
5
Regulation of gap junction conductance by calcineurin through Cx43 phosphorylation: implications for action potential conduction.
Pflugers Arch. 2016 Nov;468(11-12):1945-1955. doi: 10.1007/s00424-016-1885-7. Epub 2016 Oct 19.
6
Remodeling of Cardiac Gap Junctional Cell-Cell Coupling.
Cells. 2021 Sep 14;10(9):2422. doi: 10.3390/cells10092422.
7
Electrical coupling of cardiomyocyte sheets occurs rapidly via functional gap junction formation.
Biomaterials. 2006 Sep;27(27):4765-74. doi: 10.1016/j.biomaterials.2006.04.034. Epub 2006 Jun 5.
8
Remodeling of gap junctions in ischemic and nonischemic forms of heart disease.
J Membr Biol. 2007 Aug;218(1-3):65-71. doi: 10.1007/s00232-007-9031-2. Epub 2007 Jun 22.
9
The role of myocardial gap junctions in electrical conduction and arrhythmogenesis.
Cardiovasc Pathol. 2001 Jul-Aug;10(4):169-77. doi: 10.1016/s1054-8807(01)00078-3.
10
A simulation study of cellular hypertrophy and connexin lateralization in cardiac tissue.
Biophys J. 2010 Nov 3;99(9):2821-30. doi: 10.1016/j.bpj.2010.09.010.
引用本文的文献
1
evaluation of 3D-printed conductive chitosan-polyaniline scaffolds with exosome release for enhanced angiogenesis and cardiomyocyte protection.
RSC Adv. 2025 May 20;15(21):16826-16844. doi: 10.1039/d5ra02940f. eCollection 2025 May 15.
2
Molecular Mechanisms Underlying Heart Failure and Their Therapeutic Potential.
Cells. 2025 Feb 20;14(5):324. doi: 10.3390/cells14050324.
3
The effects of inflammation on connexin 43 in chronic Chagas disease cardiomyopathy.
Front Immunol. 2024 Jul 29;15:1440662. doi: 10.3389/fimmu.2024.1440662. eCollection 2024.
4
Glycation in the cardiomyocyte.
Vitam Horm. 2024;125:47-88. doi: 10.1016/bs.vh.2024.04.005. Epub 2024 May 24.
5
Looking both ways: Electroactive biomaterials with bidirectional implications for dynamic cell-material crosstalk.
Biophys Rev (Melville). 2024 May 8;5(2):021303. doi: 10.1063/5.0181222. eCollection 2024 Jun.
6
Endothelial cell dysfunction in cardiac disease: driver or consequence?
Front Cell Dev Biol. 2023 Oct 25;11:1278166. doi: 10.3389/fcell.2023.1278166. eCollection 2023.
7
Contemporary management of ventricular arrhythmias in heart failure.
Am J Cardiovasc Dis. 2023 Aug 15;13(4):207-221. eCollection 2023.
8
Structure and Function of Cochlear Gap Junctions and Implications for the Translation of Cochlear Gene Therapies.
Front Cell Neurosci. 2019 Nov 27;13:529. doi: 10.3389/fncel.2019.00529. eCollection 2019.
9
Progesterone Via its Type-A Receptor Promotes Myometrial Gap Junction Coupling.
Sci Rep. 2017 Oct 17;7(1):13357. doi: 10.1038/s41598-017-13488-9.
10
Intracellular trafficking pathways of Cx43 gap junction channels.
Biochim Biophys Acta Biomembr. 2018 Jan;1860(1):40-47. doi: 10.1016/j.bbamem.2017.05.018. Epub 2017 May 30.
本文引用的文献
1
Structural and molecular mechanisms of gap junction remodeling in epicardial border zone myocytes following myocardial infarction.
Circ Res. 2009 May 8;104(9):1103-12. doi: 10.1161/CIRCRESAHA.108.190454. Epub 2009 Apr 2.
2
Structure of the connexin 26 gap junction channel at 3.5 A resolution.
Nature. 2009 Apr 2;458(7238):597-602. doi: 10.1038/nature07869.
3
A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy.
N Engl J Med. 2009 Mar 12;360(11):1075-84. doi: 10.1056/NEJMoa0808138.
4
Characterization of the molecular phenotype of two arrhythmogenic right ventricular cardiomyopathy (ARVC)-related plakophilin-2 (PKP2) mutations.
Heart Rhythm. 2008 Dec;5(12):1715-23. doi: 10.1016/j.hrthm.2008.09.009. Epub 2008 Sep 6.
5
Molecular reorganization of Cx43, Zo-1 and Src complexes during the endocytosis of gap junction plaques in response to a non-genomic carcinogen.
J Cell Sci. 2008 Dec 15;121(Pt 24):4069-78. doi: 10.1242/jcs.033373. Epub 2008 Nov 25.
6
Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory mediator-induced G-protein coupled receptor activation.
FEBS Lett. 2008 Dec 10;582(29):4039-46. doi: 10.1016/j.febslet.2008.10.043. Epub 2008 Nov 4.
7
Interaction between connexin35 and zonula occludens-1 and its potential role in the regulation of electrical synapses.
Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12545-50. doi: 10.1073/pnas.0804793105. Epub 2008 Aug 21.
8
Clathrin and Cx43 gap junction plaque endoexocytosis.
Biochem Biophys Res Commun. 2008 Oct 3;374(4):679-82. doi: 10.1016/j.bbrc.2008.07.108. Epub 2008 Jul 31.
9
Double-membrane gap junction internalization requires the clathrin-mediated endocytic machinery.
FEBS Lett. 2008 Aug 20;582(19):2887-92. doi: 10.1016/j.febslet.2008.07.024. Epub 2008 Jul 24.
10
Connexin 43 in LA-25 cells with active v-src is phosphorylated on Y247, Y265, S262, S279/282, and S368 via multiple signaling pathways.
Cell Commun Adhes. 2008 May;15(1):75-84. doi: 10.1080/15419060802014016.
Zotero 插件