Allbritton-King Jules D, García-Cardeña Guillermo
Department of Pathology, Center for Excellence in Vascular Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, United States.
Front Cell Dev Biol. 2023 Oct 25;11:1278166. doi: 10.3389/fcell.2023.1278166. eCollection 2023.
The vascular endothelium is a multifunctional cellular system which directly influences blood components and cells within the vessel wall in a given tissue. Importantly, this cellular interface undergoes critical phenotypic changes in response to various biochemical and hemodynamic stimuli, driving several developmental and pathophysiological processes. Multiple studies have indicated a central role of the endothelium in the initiation, progression, and clinical outcomes of cardiac disease. In this review we synthesize the current understanding of endothelial function and dysfunction as mediators of the cardiomyocyte phenotype in the setting of distinct cardiac pathologies; outline existing and models where key features of endothelial cell dysfunction can be recapitulated; and discuss future directions for development of endothelium-targeted therapeutics for cardiac diseases with limited existing treatment options.
血管内皮是一个多功能细胞系统，它直接影响给定组织内的血液成分和血管壁内的细胞。重要的是，这种细胞界面会对各种生化和血流动力学刺激作出关键的表型变化，驱动多种发育和病理生理过程。多项研究表明内皮在心脏病的发生、发展和临床结局中起核心作用。在本综述中，我们综合了目前对内皮功能和功能障碍的理解，它们作为不同心脏病理情况下心肌细胞表型的介质；概述了可以重现内皮细胞功能障碍关键特征的现有模型；并讨论了针对现有治疗选择有限的心脏病开发内皮靶向治疗的未来方向。
