Liu Ling, Ruddy Terrence, Dalipaj Mary, Poon Raymond, Szyszkowicz Mieczyslaw, You Hongyu, Dales Robert E, Wheeler Amanda J
Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada K1A 0K9.
J Occup Environ Med. 2009 Sep;51(9):1088-98. doi: 10.1097/JOM.0b013e3181b35144.
To investigate the associations between exposure to particulate air pollution and changes in cardiovascular function and plasma mediators in seniors.
We monitored daily indoor and outdoor black carbon and particulate matter < or = 2.5 microm (pm(2.5)) and personal pm(2.5) repeatedly for 28 nonsmoking seniors. We then measured their blood pressure, heart rate, and brachial artery function, and determined plasma mediators of inflammation, vascular function, and oxidative stress. We tested associations using mixed-effects models.
Increases in black carbon and pm2.5 were associated with increases in blood pressure, heart rate, endothelin-1, vascular endothelial growth factor, and oxidative stress marker thiobarbituric acid reactive substances, and a decrease in brachial artery diameter (P < 0.05).
Daily exposure to particulate pollution, likely traffic-related, may result in adverse effects on cardiovascular function and blood mediators that modulate vascular system in seniors.
研究老年人暴露于空气中的颗粒物污染与心血管功能及血浆介质变化之间的关联。
我们对28名不吸烟的老年人反复进行了为期28天的每日室内外黑碳和小于或等于2.5微米的颗粒物（pm2.5）以及个人pm2.5监测。然后我们测量了他们的血压、心率和肱动脉功能，并测定了炎症、血管功能和氧化应激的血浆介质。我们使用混合效应模型测试了关联性。
黑碳和pm2.5的增加与血压、心率、内皮素-1、血管内皮生长因子以及氧化应激标志物硫代巴比妥酸反应性物质的增加相关，同时肱动脉直径减小（P < 0.05）。
每日暴露于可能与交通相关的颗粒物污染中，可能会对老年人的心血管功能以及调节血管系统的血液介质产生不利影响。
