Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061 Xi'an, Shaanxi, China.
Inflamm Res. 2010 Feb;59(2):135-9. doi: 10.1007/s00011-009-0080-0. Epub 2009 Aug 22.
In view of the role of fibronectin in adhesion, signal transduction pathways and the infectious disease process, changes in serum fibronectin levels may influence disease evolution and severity in patients with hemorrhagic fever with renal syndrome (HFRS).
The levels of fibronectin were measured in serum samples from 112 patients with HFRS at various phases, and 30 healthy individuals were monitored as controls.
The serum levels of fibronectin in patients with HFRS at all clinical phases were higher than those in the controls, with the levels of patients at the fever, oliguric and polyuric phases of disease significantly different from controls (P < 0.01). The serum fibronectin concentration in the patients with more severe clinical disease types was higher than that in those with milder types. The serum fibronectin level in the more severe patient group was significantly higher than that in milder patient group at the oliguric phase (P < 0.05).
Serum fibronectin concentration in patients with HFRS was increased and associated with disease phases and severity, suggesting the value of detection of fibronectin levels for evaluating HFRS disease progression and severity.
鉴于纤连蛋白在黏附、信号转导途径和传染病过程中的作用，血清纤连蛋白水平的变化可能会影响肾综合征出血热（HFRS）患者的疾病演变和严重程度。
在不同阶段测量了 112 例 HFRS 患者和 30 例健康个体的血清样本中的纤连蛋白水平。
HFRS 患者在所有临床阶段的血清纤连蛋白水平均高于对照组，发热期、少尿期和多尿期患者的水平与对照组有显著差异（P < 0.01）。临床疾病类型较重的患者的血清纤连蛋白浓度高于疾病类型较轻的患者。在少尿期，病情较重组患者的血清纤连蛋白水平明显高于病情较轻组（P < 0.05）。
HFRS 患者的血清纤连蛋白浓度升高，与疾病阶段和严重程度相关，提示检测纤连蛋白水平对评估 HFRS 疾病进展和严重程度具有价值。
