Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710061 Shaanxi Province, China.
Eur J Clin Microbiol Infect Dis. 2010 Dec;29(12):1507-11. doi: 10.1007/s10096-010-1032-x. Epub 2010 Aug 21.
Increased vascular permeability and vascular leakage are characteristic pathological changes in hemorrhagic fever with renal syndrome (HFRS). Vascular endothelial cells are the main targets of Hantaan virus, the etiological agent of the severe form of HFRS. Hantaan virus can induce extensive damage of small blood vessels and capillaries. In vitro infection of human umbilical vein endothelial cells by Hantaan virus can induce the expression of intercellular adhesion molecule-1 (ICAM-1). The involvement of this molecule is implied in human HFRS. In the present study, serum-soluble ICAM-1 (sICAM-1) levels were determined and their relationships with the clinical course and disease severity were investigated in 112 HFRS patients and 30 healthy controls. The results showed that the serum levels of sICAM-1 in HFRS patients at fever, hypotensive, oliguric, and polyuric phases were significantly higher than those in controls (p < 0.001). However, no significant differences between the serum concentrations of sICAM-1 in the milder and more severe groups of patients were observed (p > 0.05). It is suggested that sICAM-1 was involved in the progression of HFRS. Time-dependent determinations of sICAM-1 levels may be indicators for the progression of disease, and elevated levels of sICAM-1 were not suggested to be correlated to disease severity.
血管通透性增加和血管渗漏是肾综合征出血热（HFRS）的特征性病理变化。血管内皮细胞是汉坦病毒（HFRS 重型的病原体）的主要靶细胞。汉坦病毒可引起小血管和毛细血管的广泛损伤。汉坦病毒体外感染人脐静脉内皮细胞可诱导细胞间黏附分子-1（ICAM-1）的表达。该分子的参与暗示了人类 HFRS 的发病机制。本研究测定了 112 例 HFRS 患者和 30 例健康对照者血清可溶性细胞间黏附分子-1（sICAM-1）水平，并探讨其与临床病程和疾病严重程度的关系。结果表明，HFRS 患者发热、低血压、少尿和多尿期血清 sICAM-1 水平明显高于对照组（p<0.001）。然而，在病情较轻和较重的患者组之间，sICAM-1 的血清浓度没有显著差异（p>0.05）。提示 sICAM-1 参与了 HFRS 的进展。sICAM-1 水平的时间依赖性测定可能是疾病进展的指标，而升高的 sICAM-1 水平与疾病严重程度无关。
