El Hajj Ihab I, Malik Shahid M, Alwakeel Hany R, Shaikh Obaid S, Sasatomi Eizaburo, Kandil Hossam M
Department of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, United States.
World J Gastroenterol. 2009 Aug 21;15(31):3937-9. doi: 10.3748/wjg.15.3937.
Selective cyclooxygenase-2 (COX-2) inhibitors are widely used due to their efficacy and good safety profile. However, recent case reports have described varying degrees of liver injuries associated with the use of COX-2 inhibitors. We report the case of a patient who developed acute cholestatic hepatitis progressing to hepatic failure requiring liver transplantation, following a 3-d course of celecoxib for treatment of generalized muscle aches and pains. The clinical presentation, the laboratory data, as well as the liver histopathology were supportive of the putative diagnosis of drug induced liver injury.
选择性环氧化酶-2（COX-2）抑制剂因其疗效和良好的安全性而被广泛使用。然而，最近的病例报告描述了使用COX-2抑制剂相关的不同程度的肝损伤。我们报告了一例患者，在服用塞来昔布3天以治疗全身肌肉酸痛后，发生急性胆汁淤积性肝炎并进展为肝衰竭，需要进行肝移植。临床表现、实验室数据以及肝脏组织病理学均支持药物性肝损伤的推定诊断。
