Nayudu Suresh Kumar, Badipatla Shanti, Niazi Masooma, Balar Bhavna
Division of Gastroenterology and Hepatology, Bronx Lebanon Hospital Center, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10457, USA ; Department of Medicine, Bronx Lebanon Hospital Center, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10457, USA.
Case Rep Med. 2013;2013:315479. doi: 10.1155/2013/315479. Epub 2013 Jun 5.
Drug-induced liver injury (DILI) is a common clinical entity but is underreported due to various reasons. Cyclooxygenase-2 inhibitors like Celecoxib have been proven to be associated with lesser incidence of adverse drug reactions compared to other nonsteroidal anti-inflammatory drugs (NSAID). However, Celecoxib has been rarely reported to be associated with cholestasis and hepatitis. We present a young Hispanic female presented with cholestatic liver chemistries who has been taking Celecoxib for 3 weeks. Extensive workup did not support diagnosis of viral, autoimmune, or metabolic liver diseases. Liver biopsy revealed findings suggestive of secondary sclerosing cholangitis. Imaging studies were negative for large duct involvement, and endoscopy ruled out inflammatory bowel disease. Liver chemistries normalized after cessation of medication. We recommend that physician should be aware of this rare complication when prescribing Celecoxib.
药物性肝损伤（DILI）是一种常见的临床病症，但由于各种原因报告不足。与其他非甾体抗炎药（NSAID）相比，像塞来昔布这样的环氧化酶-2抑制剂已被证明与药物不良反应的发生率较低有关。然而，很少有报道称塞来昔布与胆汁淤积和肝炎有关。我们报告一名年轻的西班牙裔女性，出现胆汁淤积性肝功能异常，她服用塞来昔布已3周。广泛的检查不支持病毒性、自身免疫性或代谢性肝病的诊断。肝活检结果提示继发性硬化性胆管炎。影像学检查未发现大导管受累，内镜检查排除了炎症性肠病。停药后肝功能恢复正常。我们建议医生在开具塞来昔布处方时应意识到这种罕见的并发症。
