Department of Neuro-otology and Pain and Headache, Instituto de Neurociencias de Buenos Aires INEBA, Buenos Aires, Argentina;
Ther Clin Risk Manag. 2009 Jun;5(3):661-9. doi: 10.2147/tcrm.s3427. Epub 2009 Aug 20.
Migraine and migraine variants are common, chronic and incapacitating neurovascular disorders with a high impact on health resources. There is an extensive evidence base provided by double-blind, placebo-controlled trials showing that topiramate is a safe, effective and well tolerated drug in the management of migraine and its variants, being especially promising in the management of migraine-vertigo syndrome. Models both in the US and the UK have also shown that it offers a cost benefit when direct and indirect costs are evaluated, by reducing work loss, improving quality of life and reducing the use of increasingly scarce health resources.
偏头痛和偏头痛变异型是常见的、慢性的、使人丧失能力的神经血管疾病，对卫生资源有重大影响。双盲、安慰剂对照试验提供了广泛的证据基础，表明托吡酯是一种安全、有效且耐受性良好的药物，可用于治疗偏头痛及其变异型，在治疗偏头痛-眩晕综合征方面尤其有前途。美国和英国的模型也表明，通过减少工作损失、提高生活质量和减少日益稀缺的卫生资源的使用，在评估直接和间接成本时，它具有成本效益。
