成体神经干细胞用于细胞治疗的潜力。
Potential of adult neural stem cells for cellular therapy.
作者信息
Taupin Philippe
机构信息
National Neuroscience Institute, Singapore, Singapore.
出版信息
Biologics. 2007 Mar;1(1):53-8.
Cellular therapy is the replacement of unhealthy or damaged cells or tissues by new ones. Because neurodegenerative diseases, cerebral strokes, and traumatic injuries to the central nervous system (CNS) produce neurological deficits that result from neuronal loss, cell therapy is a prominent area of investigation for the treatment of neurological diseases and injuries. Neural progenitor and stem cells generate the main phenotyes of the nervous system, and offer a model of choice for cellular therapy in the CNS. With the confirmation that neurogenesis occurs in the adult brain, and the recent isolation and characterization in vitro of neural progenitor and stem cells from the adult CNS, new strategies are being devised and have the potential to treat a broad range of CNS diseases and injuries.
细胞疗法是用新的细胞或组织替换不健康或受损的细胞或组织。由于神经退行性疾病、脑卒中和中枢神经系统（CNS）创伤性损伤会导致神经元丢失从而产生神经功能缺损，细胞疗法是治疗神经疾病和损伤的一个重要研究领域。神经祖细胞和干细胞产生神经系统的主要表型，为中枢神经系统的细胞疗法提供了一个首选模型。随着成体脑中神经发生的确认，以及最近从成体中枢神经系统中分离和体外鉴定神经祖细胞和干细胞，正在设计新的策略，这些策略有可能治疗广泛的中枢神经系统疾病和损伤。
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