Dimov V, Gréen K
Department of Biochemistry, Karolinska Hospital, Stockholm, Sweden.
Drug Metab Dispos. 1990 Jan-Feb;18(1):107-14.
The metabolism of prostaglandin F2 alpha (PGF2 alpha) in ewes was studied after im injection of 9 beta-3H-labeled PGF2 alpha. About 75% of injected radioactivity was excreted in urine within 6 hr, whereas less than 1% was excreted in the milk over 3 days. Most identified urinary metabolites were formed through well known reactions involving oxidation of the hydroxyl group at carbon 15, saturation of double bonds, and oxidation of both carbon chains. However, some metabolites underwent more extensive oxidation of the carbon chain than had been seen before in other species. This might have taken place through catabolic activity of the gastrointestinal microflora followed by reabsorption into the circulation.
在给母羊肌肉注射9β - 3H标记的前列腺素F2α（PGF2α）后，对其代谢情况进行了研究。注射的放射性物质约75%在6小时内随尿液排出，而在3天内随乳汁排出的不到1%。大多数已鉴定出的尿液代谢物是通过涉及15位碳原子上羟基氧化、双键饱和以及两条碳链氧化的已知反应形成的。然而，一些代谢物的碳链氧化程度比之前在其他物种中观察到的更为广泛。这可能是通过胃肠道微生物群的分解代谢活动，然后再吸收进入循环系统而发生的。
