Steffenrud S
Drug Metab Dispos. 1983 May-Jun;11(3):255-65.
Tritium-labeled 9-deoxo-16,16-dimethyl-9-methylene prostaglandin E2 was administered by intravenous injection into humans. The initial half-life in plasma was determined to be about 3 min. About 35% of the injected radioactivity was excreted in the urine and about 55% in the feces. Twenty-three urinary metabolites were identified. The metabolites included beta-oxidized and omega-oxidized products as well as metabolites in which the 9-methylene group had been biotransformed.
将氚标记的9-脱氧-16,16-二甲基-9-亚甲基前列腺素E2通过静脉注射给予人体。血浆中的初始半衰期测定为约3分钟。注入的放射性约35%经尿液排出，约55%经粪便排出。鉴定出23种尿液代谢物。这些代谢物包括β-氧化和ω-氧化产物以及9-亚甲基基团已发生生物转化的代谢物。
