环孢素A一种新型人体代谢物的分离与鉴定：二氢环孢素A M17
Isolation and identification of a novel human metabolite of cyclosporin A: dihydro-CsA M17.
作者信息
Meier G P, Park S B, Yee G C, Gmur D J
机构信息
Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle 98195.
出版信息
Drug Metab Dispos. 1990 Jan-Feb;18(1):68-71.
A novel metabolite of cyclosporin A was observed in human blood and urine. An analytical sample of this metabolite was isolated from human urine and the structure was determined to be (8-hydroxy-6,7-dihydro-MeBMT1) cyclosporin based on the 1H-NMR, 13C-NMR, FAB-MS, and HPLC characteristics of the biological sample as well as by comparison with a synthetically derived authentic sample. The significance of this metabolite in terms of the pathway by which cyclosporin A is metabolized is discussed.
在人血液和尿液中观察到环孢素A的一种新型代谢物。从人尿液中分离出该代谢物的分析样品，并根据生物样品的1H-NMR、13C-NMR、FAB-MS和HPLC特征以及与合成得到的对照品比较，确定其结构为(8-羟基-6,7-二氢-MeBMT1)环孢素。讨论了这种代谢物在环孢素A代谢途径方面的意义。
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