美国军事人员中的2型单纯疱疹病毒和艾滋病毒感染：对健康预防计划的影响。

Herpes simplex virus type 2 and HIV infection among US military personnel: implications for health prevention programmes.

作者信息

Bautista C T, Singer D E, O'Connell R J, Crum-Cianflone N, Agan B K, Malia J A, Sanchez J L, Peel S A, Michael N L, Scott P T

机构信息

US Military HIV Research Program, Division of Retrovirology, Walter Reed Army Institute of Research (WRAIR), Suite 250, Rockville, MD 20850, USA.

出版信息

Int J STD AIDS. 2009 Sep;20(9):634-7. doi: 10.1258/ijsa.2008.008413.

DOI:10.1258/ijsa.2008.008413

PMID:19710337

Abstract

US military personnel are routinely screened for HIV infection. Herpes simplex virus type 2 (HSV-2) is a risk factor for HIV acquisition. To determine the association between HSV-2 and HIV, a matched case-control study was conducted among US Army and Air Force service members with incident HIV infections (cases) randomly matched with two HIV-uninfected service members (controls) between 2000 and 2004. HSV-2 prevalence was significantly higher among cases (30.3%, 138/456) than among controls (9.7%, 88/912, P < 0.001). HSV-2 was strongly associated with HIV in univariate (odds ratio [OR] = 4.2, 95% confidence interval [CI] = 3.1-5.8) and multiple analyses (adjusted [OR] = 3.9, 95% CI = 2.8-5.6). The population attributable risk percentage of HIV infection due to HSV-2 was 23%. Identifying HSV-2 infections may afford the opportunity to provide targeted behavioural interventions that could decrease the incidence of HIV infections in the US military population; further studies are needed.

摘要

美国军事人员会定期接受艾滋病毒感染筛查。2型单纯疱疹病毒（HSV-2）是感染艾滋病毒的一个风险因素。为了确定HSV-2与艾滋病毒之间的关联，在2000年至2004年期间，对美国陆军和空军中感染艾滋病毒的现役军人（病例）进行了一项匹配病例对照研究，这些病例与两名未感染艾滋病毒的现役军人（对照）进行随机匹配。病例组中HSV-2的患病率（30.3%，138/456）显著高于对照组（9.7%，88/912，P<0.001）。在单因素分析（优势比[OR]=4.2，95%置信区间[CI]=3.1-5.8）和多因素分析（校正后[OR]=3.9，95%CI=2.8-5.6）中，HSV-2与艾滋病毒密切相关。HSV-2导致的艾滋病毒感染人群归因风险百分比为23%。识别HSV-2感染可能提供机会实施有针对性的行为干预措施，从而降低美国军人中艾滋病毒感染的发生率；还需要进一步研究。